Evidence map›Paper›PMID 38892263›Full record

ArticleInternational journal of molecular sciences2024

Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation.

Stephanie A Azzopardi, Hsiu-Yi Lu, Sebastien Monette, Ariana I Rabinowitsch, Jane E Salmon, Hiroaki Matsunami, Carl P Blobel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie A AzzopardiWeill Cornell Medicine/Rockefeller University/Memorial Sloan-Kettering Cancer Center, Tri-Institutional MD-PhD Program, New York, NY 10021, USA.ORCID 0000-0002-9585-9234
Hsiu-Yi LuDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Sebastien MonetteTri-Institutional Laboratory of Comparative Pathology, Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10021, USA.
Ariana I RabinowitschWeill Cornell Medicine/Rockefeller University/Memorial Sloan-Kettering Cancer Center, Tri-Institutional MD-PhD Program, New York, NY 10021, USA.
Jane E SalmonAutoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0000-0001-9113-7122
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-8850-2608
Carl P BlobelWeill Cornell Medicine/Rockefeller University/Memorial Sloan-Kettering Cancer Center, Tri-Institutional MD-PhD Program, New York, NY 10021, USA.ORCID 0000-0001-5053-3137

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Enhancing olfactory receptor expression for biochemical studies of odorant-receptor interactionsR01DC020353 · NIDCD · DUKE UNIVERSITY · PI Aashish Manglik, Hiroaki Matsunami · 2022 to 2026
$3.3M
HSS Research Institute Rheumatology TrainingT32AR071302 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ALESSANDRA B PERNIS, Jane E Salmon · 2017 to 2026
$2.3M
Structural dynamics of human odorant receptors in olfactionR01DC021585 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aashish Manglik, Hiroaki Matsunami · 2024 to 2026
$2.0M
Role of iRhoms and ADAM17 in EGFR and TNFalpha signalingR35GM134907 · NIGMS · HOSPITAL FOR SPECIAL SURGERY · PI BLOBEL, CARL PETER · 2020 to 2024
$2.0M
NCI NIH HHS P30 CA008748NIAMS NIH HHS T32 AR071302NIDCD NIH HHS R01 DC020353NIDCD NIH HHS R01 DC021585NIGMS NIH HHS R35 GM134907NIGMS NIH HHS T32 GM007739NIH HHS DC021585NIH HHS P30 CA008748NIH HHS R01 DC020353NIH HHS R35 GM134907NIH HHS T32AR071302NIH HHS T32GM007739
6 · The paper itself

Abstract

The cell surface metalloprotease ADAM17 (a disintegrin and metalloprotease 17) and its binding partners iRhom2 and iRhom1 (inactive Rhomboid-like proteins 1 and 2) modulate cell-cell interactions by mediating the release of membrane proteins such as TNFα (Tumor necrosis factor α) and EGFR (Epidermal growth factor receptor) ligands from the cell surface. Most cell types express both iRhoms, though myeloid cells exclusively express iRhom2, and iRhom1 is the main iRhom in the mouse brain. Here, we report that iRhom2 is uniquely expressed in olfactory sensory neurons (OSNs), highly specialized cells expressing one olfactory receptor (OR) from a repertoire of more than a thousand OR genes in mice.

Indexed as

Olfactory Receptor NeuronsReceptors, OdorantADAM17 ProteinAnimalsCarrier ProteinsGene Expression RegulationHumansMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutOlfactory MucosaSmellADAM17 ProteinAdam17 protein, mouseCarrier ProteinsiRhom2 protein, mouseMembrane ProteinsReceptors, OdorantADAM17 (a disintegrin and metalloprotease 17)G-protein coupled receptor (GPCR)iRhom2 (inactive Rhomboid-like protein 2)olfactory epithelium (OE)olfactory receptor (OR)olfactory sensory neuron (OSN)RNAScope in situ hybridization (ISH)RNAseqsingle-cell RNAseq analysis

Identifiers

PMID38892263
PMCPMC11173328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.