Evidence map›Paper›PMID 38892218›Full record

ArticleInternational journal of molecular sciences2024

Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients.

Maria Camila Trillos-Almanza, Mateo Chvatal-Medina, Margery A Connelly, Han Moshage, TransplantLines Investigators, Stephan J L Bakker, Vincent E de Meijer, Hans Blokzijl, Robin P F Dullaart

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272841 (TransplantLines), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03272841 unknown statusnot on this map

TransplantLines: the Transplantation Biobank

Typeobservational_patient_registrySponsorUniversity Medical Center GroningenRan2015 to 2021Enrolled3,000ConditionsSolid Organ Tranplant Recipients, 18+ Years
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Gut microbes · 2026
    Review
  2. Article
  3. Observational
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria Camila Trillos-AlmanzaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-9714-5809
Mateo Chvatal-MedinaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-4310-5657
Margery A ConnellyLabcorp, 100 Perimeter Park, Morrisville, NC 27560, USA.ORCID 0000-0002-3917-592X
Han MoshageDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-4764-0246
TransplantLines InvestigatorsGroningen Institute for Organ Transplantation, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands.
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3356-6791
Vincent E de MeijerDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-7900-5917
Hans BlokzijlDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-4240-7506
Robin P F DullaartDepartment of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-3844-5254

Funding

Astellas BV project code: TransplantLines Biobank and Cohort studyChiesi Pharmaceuticals BV project code: PA-SP/PRJ-2020-9136Dutch Ministry of Economic Affairs and Climate Policy project code: PPP-2019-032 and PPP-2022-015NWO/TTW project code: 14939The Dutch Kidney Foundation Grant E.033
6 · The paper itself

Abstract

Liver transplant recipients (LTRs) have lower long-term survival rates compared with the general population. This underscores the necessity for developing biomarkers to assess post-transplantation mortality. Here we compared plasma trimethylamine-N-oxide (TMAO) levels with those in the general population, investigated its determinants, and interrogated its association with all-cause mortality in stable LTRs. Plasma TMAO was measured in 367 stable LTRs from the TransplantLines cohort (NCT03272841) and in 4837 participants from the population-based PREVEND cohort. TMAO levels were 35% higher in LTRs compared with PREVEND participants (4.3 vs. 3.2 µmol/L,

Indexed as

BiomarkersLiver TransplantationMethylaminesAdultAgedFemaleHumansMaleMiddle AgedTransplant RecipientsBiomarkersMethylaminestrimethyloxamineliver transplantationmicrobiotaNMR spectroscopyPrevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort studyTransplantLines cohort and biobank studytrimethylamine-N-oxide

Identifiers

PMID38892218
PMCPMC11172608

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.