Evidence map›Paper›PMID 38892210›Full record

ArticleInternational journal of molecular sciences2024

Transcriptional Up-Regulation of FBXW7 by K

Susumu Ohya, Hiroaki Kito, Junko Kajikuri, Yohei Yamaguchi, Miki Matsui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susumu OhyaDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.ORCID 0000-0002-5765-0667
Hiroaki KitoDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Junko KajikuriDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.ORCID 0000-0003-0598-0733
Yohei YamaguchiDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Miki MatsuiDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.

Funding

Ministry of Education, Culture, Sports, Science and Technology 2312001The Salt Science Research Foundation, Japan 2324
6 · The paper itself

Abstract

The tumor suppressor gene F-box and WD repeat domain-containing (FBXW) 7 reduces cancer stemness properties by promoting the protein degradation of pluripotent stem cell markers. We recently demonstrated the transcriptional repression of FBXW7 by the three-dimensional (3D) spheroid formation of several cancer cells. In the present study, we found that the transcriptional activity of FBXW7 was promoted by the inhibition of the Ca

Indexed as

F-Box-WD Repeat-Containing Protein 7Gene Expression Regulation, NeoplasticNF-E2-Related Factor 2Prostatic NeoplasmsSignal TransductionSpheroids, CellularCell Line, TumorHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMaleMicroRNAsProto-Oncogene Proteins c-aktUp-RegulationF-Box-WD Repeat-Containing Protein 7FBXW7 protein, humanIntermediate-Conductance Calcium-Activated Potassium ChannelsKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMicroRNAsNFE2L2 protein, humanNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktCa2+-activated K+ channelcancer stemnessC/EBPc-MycFBXW7KCa1.1miR223Nrf2protein degradationspheroid

Identifiers

PMID38892210
PMCPMC11172474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.