Evidence map›Paper›PMID 38892206›Full record

ArticleInternational journal of molecular sciences2024

Effects of Fucoidans on Activated Retinal Microglia.

Philipp Dörschmann, Florentine Hunger, Hannah Schroth, Sibei Chen, Georg Kopplin, Johann Roider, Alexa Klettner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Philipp DörschmannDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.
Florentine HungerDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.
Hannah SchrothDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.
Sibei ChenDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.
Georg KopplinAlginor ASA, Haraldsgata 162, 5525 Haugesund, Norway.ORCID 0000-0001-5002-1465
Johann RoiderDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.
Alexa KlettnerDepartment of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.ORCID 0000-0002-2709-1059

Funding

Helmut-Ecker foundation 01/20
6 · The paper itself

Abstract

Sulfated marine polysaccharides, so-called fucoidans, have been shown to exhibit anti-inflammatory and immunomodulatory activities in retinal pigment epithelium (RPE). In this study, we tested the effects of different fucoidans (and of fucoidan-treated RPE cells) on retinal microglia to investigate whether its anti-inflammatory effect can be extrapolated to the innate immune cells of the retina. In addition, we tested whether fucoidan treatment influenced the anti-inflammatory effect of RPE cells on retinal microglia. Three fucoidans were tested (FVs from

Indexed as

Cell SurvivalMicrogliaPolysaccharidesRetinal Pigment EpitheliumAnimalsAnti-Inflammatory AgentsCell LineCytokinesLipopolysaccharidesPhagocytosisRetinaSwineAnti-Inflammatory AgentsCytokinesfucoidanLipopolysaccharidesPolysaccharidesFucus vesiculosusgene expressioninterleukinLaminaria hyperborealipopolysaccharide (LPS)nitric oxide synthase 2 (NOS2)phagocytosissulfated fucantoll-like receptortumor necrosis factor alpha (TNFα)

Identifiers

PMID38892206
PMCPMC11173224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.