Evidence map›Paper›PMID 38892166›Full record

ArticleInternational journal of molecular sciences2024

Disrupting EGFR-HER2 Transactivation by Pertuzumab in HER2-Positive Cancer: Quantitative Analysis Reveals EGFR Signal Input as Potential Predictor of Therapeutic Outcome.

László Ujlaky-Nagy, János Szöllősi, György Vereb

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

László Ujlaky-NagyDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
János SzöllősiDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
György VerebDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.ORCID 0000-0003-2157-3265

Funding

Hungarian State and the European Regional Development Fund GINOP-2.3.2-15-2016-00044Hungarian State and the European Regional Development Fund GINOP-2.3.3-15-2016-00003National Research, Development and Innovation Office, Hungary OTKA K143771University of Debrecen Program for Scientific Publication S/N
6 · The paper itself

Abstract

Pertuzumab (Perjeta

Indexed as

Antibodies, Monoclonal, HumanizedBreast NeoplasmsCell ProliferationErb-b2 Receptor Tyrosine KinasesErbB ReceptorsSignal TransductionAntineoplastic Agents, ImmunologicalCell Line, TumorFemaleFluorescence Resonance Energy TransferHumansTranscriptional ActivationAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalEGFR protein, humanERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesErbB Receptorspertuzumabconfocal microscopyEGFRepidermal growth factor receptorErbB2FCSfluorescence correlation spectroscopyfluorescence cross-correlation spectroscopy (FCCS)Förster resonance energy transfer (FRET)HER2pertuzumab (Perjeta®)targeted antibody therapytrastuzumab (Herceptin®, TrazimeraTM)

Identifiers

PMID38892166
PMCPMC11173106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.