Evidence map›Paper›PMID 38892159›Full record

ArticleInternational journal of molecular sciences2024

Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes.

Dragica Mićanović, Suzana Stanisavljević, Hanluo Li, Ivan Koprivica, Natalija Jonić, Ivana Stojanović, Vuk Savković, Tamara Saksida

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dragica MićanovićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0003-3242-6869
Suzana StanisavljevićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0003-0781-8828
Hanluo LiNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei University of Technology, Wuhan 430068, China.ORCID 0000-0001-9109-2972
Ivan KoprivicaDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
Natalija JonićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
Ivana StojanovićDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.ORCID 0000-0002-8542-1327
Vuk SavkovićDepartment of Cranial Maxillofacial Plastic Surgery, University Clinic Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-3832-4281
Tamara SaksidaDepartment of Immunology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.

Funding

Department of Cranial Maxillofacial Plastic Surgery, University Clinic Leipzig Household Budget ClinicGerman Research Council (DFG) SFB TRR 67 B12 to VS and B3 to JS and SFHubei Province Natural Science Foundation 2021CFB289 to Dr. Hanluo LiMinistry of Science, Technological Development and Innovations of the Republic of Serbia 451-03-47/2023-01/200007Saxon Ministry of Science and Fine Arts SMWK 34707004 to Saxon Incubator for Clinical Translation (SIKT Teilprojekt 34707001) to V.S.Science Fund of the Republic of Serbia Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, (project T1DmCell)
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are known for their immunosuppressive properties. Based on the demonstrated anti-inflammatory effect of mouse MSCs from hair follicles (moMSCORS) in a murine wound closure model, this study evaluates their potential for preventing type 1 diabetes (T1D) in C57BL/6 mice. T1D was induced in C57BL/6 mice by repeated low doses of streptozotocin. moMSCORS were injected intravenously on weekly basis. moMSCORS reduced T1D incidence, the insulitis stage, and preserved insulin production in treated animals. moMSCORS primarily exerted immunomodulatory effects by inhibiting CD4

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Hair FollicleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMice, Inbred C57BLAnimalsCD4-Positive T-LymphocytesCell ProliferationMaleMicePancreasautoimmunityimmunomodulationinsulin expressionmouse modelMSC therapystreptozotocin

Identifiers

PMID38892159
PMCPMC11172537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.