Evidence map›Paper›PMID 38892139›Full record

ReviewInternational journal of molecular sciences2024

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring.

Benjamin N Nelson, Jacob E Friedman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin N NelsonHarold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Jacob E FriedmanHarold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-6426-1512

Funding

Role of the Macrophage in Developmentally Programmed NAFLDR01DK121951 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FRIEDMAN, JACOB E, JONSCHER, KAREN R · 2020 to 2023
$2.3M
Maternal Obesity and Pediatric NAFLD: Fetal Origins and Long-term outcomes in Non Human PrimatesR01DK128416 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FRIEDMAN, JACOB E · 2021 to 2024
$2.3M
NIDDK NIH HHS R01 DK121951NIDDK NIH HHS R01 DK128416NIH HHS 5R01DK121951-04A1NIH HHS 5R01DK128416-03A1
6 · The paper itself

Abstract

Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with obesity have reduced immune responses to stimuli which increase susceptibility to infections. Recently, maternal western-style diets (WSDs), high in fat and simple sugars, have been associated with skewing neonatal immune cell development, and recent evidence suggests that dysregulation of innate immunity in early life has long-term consequences on metabolic diseases and behavioral disorders in later life. Several factors contribute to abnormal innate immune tolerance or trained immunity, including changes in gut microbiota, metabolites, and epigenetic modifications. Critical knowledge gaps remain regarding the mechanisms whereby these factors impact fetal and postnatal immune cell development, especially in precursor stem cells in bone marrow and fetal liver. Components of the maternal microbiota that are transferred from mothers consuming a WSD to their offspring are understudied and identifying cause and effect on neonatal innate and adaptive immune development needs to be refined. Tools including single-cell RNA-sequencing, epigenetic analysis, and spatial location of specific immune cells in liver and bone marrow are critical for understanding immune system programming. Considering the vital role immune function plays in offspring health, it will be important to understand how maternal diets can control developmental programming of innate and adaptive immunity.

Indexed as

Diet, WesternFetal DevelopmentPrenatal Exposure Delayed EffectsAnimalsEpigenesis, GeneticFemaleFetusGastrointestinal MicrobiomeHumansImmune SystemImmunity, InnateMaternal Nutritional Physiological PhenomenaPregnancyepigeneticsfetal–maternal healthinnate immune regulationmaternal obesitymetabolitesmicrobiomemulti-omics

Identifiers

PMID38892139
PMCPMC11172957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.