Galactic Cosmic Ray Particle Exposure Does Not Increase Protein Levels of Inflammation or Oxidative Stress Markers in Rat Microglial Cells In Vitro.

Danielle S Cahoon, Derek R Fisher, Bernard M Rabin, Stefania Lamon-Fava, Dayong Wu, Tong Zheng, Barbara Shukitt-Hale

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Danielle S CahoonUSDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-3243-1804

Derek R FisherUSDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Bernard M RabinDepartment of Psychology, University of Maryland, Baltimore County (UMBC), Baltimore, MD 21250, USA.

Stefania Lamon-FavaUSDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Dayong WuUSDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Tong ZhengUSDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Barbara Shukitt-HaleUSDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-3810-1910

Funding

NASA NNJ16HP45I, NNX16AE06GUnited States Department of Agriculture 8050-51000-102-000-D

6 · The paper itself

Abstract

Astronauts on exploratory missions will be exposed to galactic cosmic rays (GCR), which can induce neuroinflammation and oxidative stress (OS) and may increase the risk of neurodegenerative disease. As key regulators of inflammation and OS in the CNS, microglial cells may be involved in GCR-induced deficits, and therefore could be a target for neuroprotection. This study assessed the effects of exposure to helium (

Indexed as

BiomarkersCosmic RadiationInflammationMicrogliaOxidative StressAnimalsCyclooxygenase 2HeliumIronNADPH Oxidase 2Nitric Oxide Synthase Type IIRatsTumor Necrosis Factor-alphaBiomarkersCyclooxygenase 2HeliumIronNADPH Oxidase 2Nitric Oxide Synthase Type IITumor Necrosis Factor-alphagalactic cosmic raysinflammationmicrogliaoxidative stressspace-radiation

Identifiers

PMID38892109

DOI10.3390/ijms25115923

PMCPMC11172496

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.