Evidence map›Paper›PMID 38892071›Full record

ArticleInternational journal of molecular sciences2024

1,3,5-Triazine as Branching Connector for the Construction of Novel Antimicrobial Peptide Dendrimers: Synthesis and Biological Characterization.

Rotimi Sheyi, Jessica T Mhlongo, Marta Jorba, Ester Fusté, Anamika Sharma, Miguel Viñas, Fernando Albericio, Paula Espinal, Beatriz G de la Torre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rotimi SheyiPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, KwaZulu-Natal, South Africa.
Jessica T MhlongoPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, KwaZulu-Natal, South Africa.
Marta JorbaLaboratory of Molecular Microbiology & Antimicrobials, Department of Pathology and Experimental Therapeutics, Faculty of Medicine & Health Sciences, IDIBELL-University of Barcelona, Campus Bellvitge, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-8492-6331
Ester FustéLaboratory of Molecular Microbiology & Antimicrobials, Department of Pathology and Experimental Therapeutics, Faculty of Medicine & Health Sciences, IDIBELL-University of Barcelona, Campus Bellvitge, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-3561-9765
Anamika SharmaPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, KwaZulu-Natal, South Africa.ORCID 0000-0003-1282-5838
Miguel ViñasLaboratory of Molecular Microbiology & Antimicrobials, Department of Pathology and Experimental Therapeutics, Faculty of Medicine & Health Sciences, IDIBELL-University of Barcelona, Campus Bellvitge, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0003-2073-3386
Fernando AlbericioPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, KwaZulu-Natal, South Africa.ORCID 0000-0002-8946-0462
Paula EspinalLaboratory of Molecular Microbiology & Antimicrobials, Department of Pathology and Experimental Therapeutics, Faculty of Medicine & Health Sciences, IDIBELL-University of Barcelona, Campus Bellvitge, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-1014-8936
Beatriz G de la TorreSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, KwaZulu-Natal, South Africa.ORCID 0000-0001-8521-9172

Funding

Marato TV3 BARNAPA 201/C/2018National Research Foundation Blue Sky's Research program 120386
6 · The paper itself

Abstract

Peptides displaying antimicrobial properties are being regarded as useful tools to evade and combat antimicrobial resistance, a major public health challenge. Here we have addressed dendrimers, attractive molecules in pharmaceutical innovation and development displaying broad biological activity. Triazine-based dendrimers were fully synthesized in the solid phase, and their antimicrobial activity and some insights into their mechanisms of action were explored. Triazine is present in a large number of compounds with highly diverse biological targets with broad biological activities and could be an excellent branching unit to accommodate peptides. Our results show that the novel peptide dendrimers synthesized have remarkable antimicrobial activity against Gram-negative bacteria (

Indexed as

DendrimersEscherichia coliMicrobial Sensitivity TestsTriazinesAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesPseudomonas aeruginosaAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesDendrimersTriazines2,4,6-Trichloro-1,3,5-triazine (TCT)antimicrobialsefflux pump inhibitorsmultidrug-resistant bacteria (MDR)peptide dendrimerssolid-phase peptide synthesis (SPPS)

Identifiers

PMID38892071
PMCPMC11172478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.