Evidence map›Paper›PMID 38891994›Full record

ArticleInternational journal of molecular sciences2024

Genetic Insights into Colorectal Cancer: Evaluating PI3K/AKT Signaling Pathway Genes Expression.

Rafał Świechowski, Jacek Pietrzak, Agnieszka Wosiak, Michał Mik, Ewa Balcerczak

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rafał ŚwiechowskiDepartment of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0003-2923-273X
Jacek PietrzakDepartment of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0002-9187-1199
Agnieszka WosiakDepartment of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0002-1732-0233
Michał MikDepartment of General and Colorectal Surgery, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland.ORCID 0000-0001-6290-1806
Ewa BalcerczakDepartment of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0001-5257-2914

Funding

Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz 503/3-015-02/503-31-001National Science Center 2022/06/X/NZ5/00740
6 · The paper itself

Abstract

The PI3K/AKT pathway plays a pivotal role in cellular processes, and its dysregulation is implicated in various cancers, including colorectal cancer. The present study correlates the expression levels of critical genes (

Indexed as

Colorectal NeoplasmsGene Expression Regulation, NeoplasticProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSignal TransductionAdultAgedAged, 80 and overClass I Phosphatidylinositol 3-KinasesFemaleForkhead Box Protein O1HumansMaleMiddle AgedPhosphatidylinositol 3-KinasesAKT1 protein, humanClass I Phosphatidylinositol 3-KinasesForkhead Box Protein O1FOXO1 protein, humanPhosphatidylinositol 3-KinasesPIK3CA protein, humanProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanAKT1colorectal cancergene expressionPI3K/AKT pathwayPIK3CA

Identifiers

PMID38891994
PMCPMC11172330

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.