Evidence map›Paper›PMID 38891951›Full record

ArticleInternational journal of molecular sciences2024

Comparative Bioinformatic Analysis Reveals Conserved Regions in SARS-CoV-2 Genome for RAPID Pandemic Response.

Marcela Viviana Karpuj, D R Shaytov, Yonat Shemer-Avni, Michael Gideon, Zakharia M Frenkel, Sarit Sivan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcela Viviana KarpujDepartment of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel.ORCID 0000-0002-2209-2175
D R ShaytovDepartment of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel.
Yonat Shemer-AvniLaboratory of Clinical Virology, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Michael GideonDepartment of Neurosurgery, Soroka Medical Center, Beer-Sheva 84101, Israel.
Zakharia M FrenkelDepartment of Software Engineering, Braude College of Engineering, Karmiel 2161002, Israel.
Sarit SivanDepartment of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel.ORCID 0000-0002-6074-8032

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the face of the SARS-CoV-2 pandemic, characterized by the virus's rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2, offering a strategic advantage in the fight against this and future pathogens. Our approach has enabled the creation of a diagnostic assay that is not only rapid, reliable, and cost-effective but also possesses a remarkable capacity to detect a wide array of current and prospective variants with unmatched precision. The significance of our findings lies in the demonstration that focusing on these conserved genomic sequences can significantly enhance our preparedness for and response to emerging infectious diseases. By providing a blueprint for the development of versatile diagnostic tools and therapeutics, this research paves the way for a more effective global pandemic response strategy.

Indexed as

Computational BiologyConserved SequenceCOVID-19Genome, ViralSARS-CoV-2HumansPandemicsbioinformatic analysisconserved genomic regionsdiagnostic assaypoint-of-care testingrapid testingSARS-CoV-2

Identifiers

PMID38891951
PMCPMC11172030

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.