Evidence map›Paper›PMID 38891891›Full record

ArticleInternational journal of molecular sciences2024

Matrix Remodeling Enzymes as Potential Fluid Biomarkers of Neurodegeneration in Alzheimer's Disease.

Jelena Bašić, Vuk Milošević, Branka Djordjević, Vladana Stojiljković, Milica Živanović, Nikola Stefanović, Aleksandra Aracki Trenkić, Dragan Stojanov, Tatjana Jevtović Stoimenov, Ivana Stojanović

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jelena BašićDepartment of Biochemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-9221-561X
Vuk MiloševićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-2434-8277
Branka DjordjevićDepartment of Biochemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Vladana StojiljkovićDepartment of Biochemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-2862-5665
Milica ŽivanovićCenter for Radiology, University Clinical Center Niš, 18000 Niš, Serbia.ORCID 0000-0003-1988-7249
Nikola StefanovićDepartment of Pharmacy, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Aleksandra Aracki TrenkićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Dragan StojanovFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Tatjana Jevtović StoimenovDepartment of Biochemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Ivana StojanovićDepartment of Biochemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.

Funding

Faculty of Medicine University of Niš, Serbia INT-MFN-44Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-65/2024-03/200113
6 · The paper itself

Abstract

This study investigated the diagnostic accuracy of plasma biomarkers-specifically, matrix metalloproteinase (MMP-9), tissue inhibitor of metalloproteinase (TIMP-1), CD147, and the MMP-/TIMP-1 ratio in patients with Alzheimer's disease (AD) dementia. The research cohort comprised patients diagnosed with probable AD dementia and a control group of cognitively unimpaired (CU) individuals. Neuroradiological assessments included brain magnetic resonance imaging (MRI) following dementia protocols, with subsequent volumetric analysis. Additionally, cerebrospinal fluid (CSF) AD biomarkers were classified using the A/T/N system, and apolipoprotein E (

Indexed as

Alzheimer DiseaseBiomarkersMagnetic Resonance ImagingMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1AgedAged, 80 and overApolipoprotein E4FemaleHippocampusHumansMaleMiddle AgedROC CurveApolipoprotein E4BiomarkersMatrix Metalloproteinase 9MMP9 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1Alzheimer’s diseaseAPOE ε4hippocampal volumematrix metalloproteinase-9tissue inhibitor of metalloproteinase-1

Identifiers

PMID38891891
PMCPMC11171655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.