Evidence map›Paper›PMID 38891878›Full record

ReviewInternational journal of molecular sciences2024

Long Non-Coding RNAs in Neuroblastoma: Pathogenesis, Biomarkers and Therapeutic Targets.

Niels Vercouillie, Zhiyao Ren, Eva Terras, Tim Lammens

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Niels VercouillieDepartment of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Zhiyao RenDepartment of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-7598-9584
Eva TerrasDepartment of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0003-2205-1207
Tim LammensDepartment of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-8733-4027

Funding

Chinese Scholarship Council (CSC) 202208340021vzw Kinderkankerfonds grant to TL
6 · The paper itself

Abstract

Neuroblastoma is the most common malignant extracranial solid tumor of childhood. Recent studies involving the application of advanced high-throughput "omics" techniques have revealed numerous genomic alterations, including aberrant coding-gene transcript levels and dysfunctional pathways, that drive the onset, growth, progression, and treatment resistance of neuroblastoma. Research conducted in the past decade has shown that long non-coding RNAs, once thought to be transcriptomic noise, play key roles in cancer development. With the recent and continuing increase in the amount of evidence for the underlying roles of long non-coding RNAs in neuroblastoma, the potential clinical implications of these RNAs cannot be ignored. In this review, we discuss their biological mechanisms of action in the context of the central driving mechanisms of neuroblastoma, focusing on potential contributions to the diagnosis, prognosis, and treatment of this disease. We also aim to provide a clear, integrated picture of future research opportunities.

Indexed as

Biomarkers, TumorGene Expression Regulation, NeoplasticNeuroblastomaRNA, Long NoncodingAnimalsHumansMolecular Targeted TherapyPrognosisBiomarkers, TumorRNA, Long Noncodingcancer hallmarkdiagnosticlong non-coding RNAneuroblastomaprognostictherapy

Identifiers

PMID38891878
PMCPMC11171840

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.