Evidence map›Paper›PMID 38891873›Full record

ArticleInternational journal of molecular sciences2024

Enhancing Heart Transplantation: Utilizing Gas-Loaded Nanocarriers to Mitigate Cold/Hypoxia Stress.

Chiara Rubeo, Gjylije Hoti, Magalì Giordano, Chiara Molinar, Manuela Aragno, Beatrice Mantuano, Stefano Comità, Saveria Femminò, Roberta Cavalli, Francesco Trotta and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chiara RubeoDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0001-8588-851X
Gjylije HotiDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, Italy.ORCID 0000-0002-0541-980X
Magalì GiordanoDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Chiara MolinarDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, Italy.
Manuela AragnoDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0002-0453-5235
Beatrice MantuanoDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Stefano ComitàDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Saveria FemminòDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0003-4644-0784
Roberta CavalliDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, Italy.
Francesco TrottaDepartment of Chemistry, University of Turin, Via P. Giuria 7, 10125 Torino, Italy.
Claudia PennaDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Pasquale PagliaroDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0002-4386-1383

Funding

Fondo Beneficenza Intesa San Paolo B/2021/0159
6 · The paper itself

Abstract

Gas-loaded nanocarriers (G-LN) show promise in improving heart transplantation (HTx) outcomes. Given their success in reducing cell death during normothermic hypoxia/reoxygenation (H/R) in vitro, we tested their integration into cardioplegic solutions and static cold storage (SCS) during simulated HTx. Wistar rat hearts underwent four hours of SCS with four G-LN variants: O

Indexed as

Heart TransplantationRats, WistarAnimalsApoptosisAutophagyGasesHemodynamicsHypoxiaMaleNanoparticlesOxygenRatsGasesOxygencardioplegic solutionshypoxia/reoxygenationmolecular signaling pathwaysnanomonomersnanospongesstatic cold storage

Identifiers

PMID38891873
PMCPMC11171608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.