Evidence map›Paper›PMID 38891849›Full record

ReviewInternational journal of molecular sciences2024

Pancreatic Cancer and Venous Thromboembolism.

Teagan Prouse, Mohammad A Mohammad, Sonali Ghosh, Narender Kumar, Ma Lorena Duhaylungsod, Rinku Majumder, Samarpan Majumder

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. Development of A Risk Assessment Model for Venous Thromboembolism among Patients with Cholangiocarcinoma.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teagan ProuseDepartment of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Mohammad A MohammadDepartment of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Sonali GhoshDepartment of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Narender KumarDepartment of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Ma Lorena DuhaylungsodDepartment of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Rinku MajumderDepartment of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0002-1727-7220
Samarpan MajumderDepartment of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0002-1831-664X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from satisfactory and surgery remains the mainstay of curative strategies. These challenges warrant identifying effective treatments for combating this deadly cancer. PDAC tumor progression is associated with the robust activation of the coagulation system. Notably, cancer-associated thrombosis (CAT) is a significant risk factor in PDAC. CAT is a concept whereby cancer cells promote thromboembolism, primarily venous thromboembolism (VTE). Of all cancer types, PDAC is associated with the highest risk of developing VTE. Hypoxia in a PDAC tumor microenvironment also elevates thrombotic risk. Direct oral anticoagulants (DOACs) or low-molecular-weight heparin (LMWH) are used only as thromboprophylaxis in PDAC. However, a precision medicine approach is recommended to determine the precise dose and duration of thromboprophylaxis in clinical setting.

Indexed as

Pancreatic NeoplasmsVenous ThromboembolismAnimalsAnticoagulantsCarcinoma, Pancreatic DuctalHumansRisk FactorsTumor MicroenvironmentAnticoagulantspancreatic ductal adenocarcinoma (PDAC)protein S (PS) 1thrombosis

Identifiers

PMID38891849
PMCPMC11171482

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.