The Significant Role of PA28αβ in CD8

Katharina Inholz, Ulrika Bader, Sarah Mundt, Michael Basler

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Cleaving Expectations: A Review of Proteasome Functional and Catalytic Diversity.Biomolecules · 2025
Review
Immunoproteasome remodeling in senescing human macrophages reveals the loss of PA28αβ capping as a hallmark of immunosenescence.Communications biology · 2025
Article
Stress transmission in social groups of mice: unveiling physiological responses, behavioral patterns, and immune dynamics.iScience · 2025
Article
Not Just PA28γ: What We Know About the Role of PA28αβ in Carcinogenesis.Biomolecules · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katharina InholzBiotechnology Institute Thurgau (BITg) at the University of Konstanz, 8280 Kreuzlingen, Switzerland.ORCID 0009-0000-0054-4989

Ulrika BaderDivision of Immunology, Department of Biology, University of Konstanz, 78464 Konstanz, Germany.

Sarah MundtInstitute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.

Michael BaslerBiotechnology Institute Thurgau (BITg) at the University of Konstanz, 8280 Kreuzlingen, Switzerland.ORCID 0000-0002-9428-2349

Funding

Deutsche Forschungsgemeinschaft GR 1517/25-1Forschungspreis Walter Enggist

6 · The paper itself

Abstract

The proteasome generates the majority of peptides presented on MHC class I molecules. The cleavage pattern of the proteasome has been shown to be changed via the proteasome activator (PA)28 alpha beta (PA28αβ). In particular, several immunogenic peptides have been reported to be PA28αβ-dependent. In contrast, we did not observe a major impact of PA28αβ on the generation of different major histocompatibility complex (MHC) classI ligands. PA28αβ-knockout mice infected with the

Indexed as

CD8-Positive T-LymphocytesGraft RejectionHistocompatibility Antigens Class IMice, KnockoutAnimalsLigandsLymphocytic choriomeningitis virusMiceMice, Inbred C57BLProteasome Endopeptidase ComplexVaccinia virusHistocompatibility Antigens Class ILigandsProteasome Endopeptidase Complexadoptive cell transferantigen presentationantigen processingCD8 T cell responsePA28αβproteasomerejection

Identifiers

PMID38891837

DOI10.3390/ijms25115649

PMCPMC11172216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.