Evidence map›Paper›PMID 38891812›Full record

ArticleInternational journal of molecular sciences2024

Characterization of Humanized Mouse Model of Organophosphate Poisoning and Detection of Countermeasures via MALDI-MSI.

Caitlin M Tressler, Benjamin Wadsworth, Samantha Carriero, Natalie Dillman, Rachel Crawford, Tae-Hun Hahm, Kristine Glunde, C Linn Cadieux

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caitlin M TresslerThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Benjamin WadsworthUnited States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Gunpowder, MD 21010, USA.
Samantha CarrieroUnited States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Gunpowder, MD 21010, USA.
Natalie DillmanThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Rachel CrawfordThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tae-Hun HahmThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-4297-4597
Kristine GlundeThe Johns Hopkins University Applied Imaging Mass Spectrometry Core and Service Center, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
C Linn CadieuxUnited States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Gunpowder, MD 21010, USA.ORCID 0000-0002-1440-2284

Funding

Platinum Accumulation in Pigmented Granules of CisplatinZ01OD022011 · OD · OFFICE OF THE DIRECTOR, NIH · PI LEAPMAN, RICHARD D · 2005 to 2006
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NIH HHS AOD22011-001-00000; MOA-AI-21002-01United States Department of Defense W81XWH22C0047
6 · The paper itself

Abstract

Organophosphoate (OP) chemicals are known to inhibit the enzyme acetylcholinesterase (AChE). Studying OP poisoning is difficult because common small animal research models have serum carboxylesterase, which contributes to animals' resistance to OP poisoning. Historically, guinea pigs have been used for this research; however, a novel genetically modified mouse strain (KIKO) was developed with nonfunctional serum carboxylase (Es1 KO) and an altered acetylcholinesterase (AChE) gene, which expresses the amino acid sequence of the human form of the same protein (AChE KI). KIKO mice were injected with 1xLD

Indexed as

AcetylcholinesteraseDisease Models, AnimalOrganophosphate PoisoningSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAcetylcholineAnimalsAtropineBrainCholinesterase InhibitorsHumansMiceMice, KnockoutAcetylcholineAcetylcholinesteraseAtropineCholinesterase Inhibitors2-PAMatropineMALDI imagingorganophosphatereactivator

Identifiers

PMID38891812
PMCPMC11172367

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.