Evidence map›Paper›PMID 38891795›Full record

ArticleInternational journal of molecular sciences2024

Clinical Significance of the Plasma Biomarker Panels in Amyloid-Negative and Tau PET-Positive Amnestic Patients: Comparisons with Alzheimer's Disease and Unimpaired Cognitive Controls.

Hsin-I Chang, Kuo-Lun Huang, Chung-Gue Huang, Chi-Wei Huang, Shu-Hua Huang, Kun-Ju Lin, Chiung-Chih Chang

Abstract readMulticenter StudyComparative Study
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsin-I ChangDepartment of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Kuo-Lun HuangDepartment of Neurology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333423, Taiwan.
Chung-Gue HuangDepartment of Medical Laboratory, Linkou Chang Gung Memorial Hospital, Department of Medical Bio-Technology and Laboratory Science, Chang Gung University, Taoyuan 333423, Taiwan.ORCID 0000-0002-0598-5684
Chi-Wei HuangDepartment of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Shu-Hua HuangDepartment of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Kun-Ju LinDepartment of Nuclear Medicine, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333423, Taiwan.ORCID 0000-0003-1933-4564
Chiung-Chih ChangDepartment of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0002-6721-2556

Funding

Chang Gung Memorial Hospital CORPG8N0041, CMRPG8J0524, CMRPG8J0843, CMRPG8K1533National Science and Technology Council, Taiwan NSTC 112-2321-B-182A-004
6 · The paper itself

Abstract

The purpose of this study was to investigate whether plasma biomarkers can help to diagnose, differentiate from Alzheimer disease (AD), and stage cognitive performance in patients with positron emission tomography (PET)-confirmed primary age-related tauopathy, termed tau-first cognitive proteinopathy (TCP) in this study. In this multi-center study, we enrolled 285 subjects with young-onset AD (YOAD;

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersPositron-Emission Tomographytau ProteinsAgedAged, 80 and overAmnesiaClinical RelevanceCognitionFemaleHippocampusHumansMaleMiddle AgedNeurofilament ProteinsAmyloid beta-PeptidesBiomarkersneurofilament protein LNeurofilament Proteinstau Proteinsflorzolotauprimary age-related tauopathypTau181tau first cognitive tauopathy

Identifiers

PMID38891795
PMCPMC11171590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.