Evidence map›Paper›PMID 38891118›Full record

ArticleCells2024

Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway.

Tomoaki Ando, Ikuo Takazawa, Zachary T Spencer, Ryoji Ito, Yoshiaki Tomimori, Zbigniew Mikulski, Kenji Matsumoto, Tohru Ishitani, Lee A Denson, Yu Kawakami and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tomoaki AndoLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.ORCID 0000-0002-8548-4424
Ikuo TakazawaLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.ORCID 0000-0003-1640-5806
Zachary T SpencerDepartment of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
Ryoji ItoLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.ORCID 0000-0003-2903-2332
Yoshiaki TomimoriLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.
Zbigniew MikulskiImaging Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-1918-9216
Kenji MatsumotoDepartment of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Tohru IshitaniInstitute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-0044, Gunma, Japan.ORCID 0000-0002-6200-7043
Lee A DensonDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Yu KawakamiLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.
Yuko KawakamiLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.
Jiro KitauraAtopy Research Center, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Yashi AhmedDepartment of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
Toshiaki KawakamiLaboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla, CA 92037, USA.ORCID 0000-0002-0427-1217

Funding

Genetic and Molecular Dissection of Wnt Pathway ActivationSupplementR35GM136233 · NIGMS · DARTMOUTH COLLEGE · PI Yasmath Ahmed · 2020 to 2026
$4.5M
Histamine-Releasing Factor Oligomers in Food AllergyR01AI146042 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KAWAKAMI, TOSHIAKI · 2019 to 2022
$2.5M
Mast cell Stat5-regulatory pathway in atopic dermatitisR01AR064418 · NIAMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KAWAKAMI, TOSHIAKI · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI146042NIAMS NIH HHS R01 AR064418NIGMS NIH HHS R35 GM136233US National Institutes of Health R01 AR064418 (T.K.), R01 AI146042 (T.K.), and R35 GM136233 (Y.A.)
6 · The paper itself

Abstract

Crohn's disease is a chronic, debilitating, inflammatory bowel disease. Here, we report a critical role of phospholipase C-β3 (PLC-β3) in intestinal homeostasis. In PLC-β3-deficient mice, exposure to oral dextran sodium sulfate induced lethality and severe inflammation in the small intestine. The lethality was due to PLC-β3 deficiency in multiple non-hematopoietic cell types. PLC-β3 deficiency resulted in reduced Wnt/β-catenin signaling, which is essential for homeostasis and the regeneration of the intestinal epithelium. PLC-β3 regulated the Wnt/β-catenin pathway in small intestinal epithelial cells (IECs) at transcriptional, epigenetic, and, potentially, protein-protein interaction levels. PLC-β3-deficient IECs were unable to respond to stimulation by R-spondin 1, an enhancer of Wnt/β-catenin signaling. Reduced expression of PLC-β3 and its signature genes was found in biopsies of patients with ileal Crohn's disease. PLC-β regulation of Wnt signaling was evolutionally conserved in

Indexed as

Crohn DiseasePhospholipase C betaWnt Signaling PathwayAnimalsbeta CateninHumansIleumIntestinal MucosaMiceMice, Inbred C57BLMice, Knockoutbeta CateninPhospholipase C betaDrosophilainflammatory bowel diseaseKO mousephospholipase C-β3Wnt/β-catenin signaling

Identifiers

PMID38891118
PMCPMC11171731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.