Evidence map›Paper›PMID 38891113›Full record

ArticleCells2024

Tigilanol Tiglate-Induced Changes in Secretome Profiles Alter C-Met Phosphorylation and Cell Surface Protein Expression in H357 Head and Neck Cancer Cells.

Frank Dickson Antwi, Tufaha Awad, Meghan Larin, Kate Heesom, Phil Lewis, Paul Reddell, Zaruhi Poghosyan, Sharon Dewitt, Ryan Moseley, Vera Knäuper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Frank Dickson AntwiSchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XY, UK.ORCID 0009-0000-1732-9767
Tufaha AwadSchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XY, UK.
Meghan LarinSchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XY, UK.
Kate HeesomBristol Proteomics Facility, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.ORCID 0000-0002-5418-5392
Phil LewisBristol Proteomics Facility, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Paul ReddellQBiotics Group, Yungaburra, QLD 4884, Australia.ORCID 0000-0002-0993-8957
Zaruhi PoghosyanSchool of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XN, UK.
Sharon DewittSchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XY, UK.ORCID 0000-0001-8169-8241
Ryan MoseleySchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XY, UK.ORCID 0000-0002-2812-6735
Vera KnäuperSchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XY, UK.ORCID 0000-0002-3965-9924

Funding

Cardiff University 522937Cardiff University BZ13033103
6 · The paper itself

Abstract

Tigilanol tiglate (TT, also known as EBC-46) is a novel, plant-derived diterpene ester possessing anticancer and wound-healing properties. Here, we show that TT-evoked PKC-dependent S

Indexed as

Head and Neck NeoplasmsProto-Oncogene Proteins c-metCell Line, TumorDiterpenesHumansMembrane ProteinsNectinsPhosphorylationProtein Kinase CSecretomeSignal TransductionSyndecan-1DiterpenesMembrane ProteinsMET protein, humanNectinsProtein Kinase CProto-Oncogene Proteins c-metSyndecan-1cancersecretome analysistherapy

Identifiers

PMID38891113
PMCPMC11171882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.