Evidence map›Paper›PMID 38891047›Full record

ReviewCells2024

The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis.

Estera Bakinowska, Aleksandra Wiktoria Bratborska, Kajetan Kiełbowski, Maciej Ćmil, Wojciech Jerzy Biniek, Andrzej Pawlik

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Estera BakinowskaDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Aleksandra Wiktoria BratborskaDepartment of Internal Medicine, Poznań University of Medical Sciences, 60-780 Poznan, Poland.ORCID 0009-0006-5288-1577
Kajetan KiełbowskiDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-8227-6753
Maciej ĆmilDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0009-0000-1594-5646
Wojciech Jerzy BiniekDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Andrzej PawlikDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-6557-1208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of a hyperplastic pannus, as well as cartilage and bone damage. The pathogenesis of RA is complex and involves broad interactions between various cells present in the inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, and T cells, among others. Under inflammatory conditions, these cells are activated, further enhancing inflammatory responses and angiogenesis and promoting bone and cartilage degradation. Novel treatment methods for RA are greatly needed, and mesenchymal stromal cells (MSCs) have been suggested as a promising new regenerative and immunomodulatory treatment. In this paper, we present the interactions between MSCs and RA-FLSs, and macrophages and T cells, and summarise studies examining the use of MSCs in preclinical and clinical RA studies.

Indexed as

Arthritis, RheumatoidMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsHumansMacrophagesSynovial MembraneSynoviocytesT-Lymphocytesfibroblast-like synoviocytesinflammationmacrophagesmesenchymal stromal cellsrheumatoid arthritis

Identifiers

PMID38891047
PMCPMC11171813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.