Evidence map›Paper›PMID 38890810›Full record

ArticleThe journal of pathology. Clinical research2024

Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma-related markers.

Sunao Ito, Akira Koshino, Chengbo Wang, Takahiro Otani, Masayuki Komura, Akane Ueki, Shunsuke Kato, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pathology. Clinical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Oncology research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sunao Ito *Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Akira Koshino *Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Chengbo WangDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Takahiro OtaniDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Masayuki KomuraDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Akane UekiDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shunsuke KatoDivision of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Hiroki TakahashiDepartment of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Masahide EbiDivision of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Naotaka OgasawaraDivision of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Toyonori TsuzukiSurgical Pathology, Aichi Medical University School of Medicine, Nagakute, Japan.ORCID 0000-0002-4855-4366
Kenji KasaiDepartment of Pathology, Aichi Medical University School of Medicine, Nagakute, Japan.
Kunio KasugaiDivision of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
Shuji TakiguchiDepartment of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Satoru TakahashiDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Shingo InagumaDepartment of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID 0000-0001-8585-8900

Funding

Japan Society for the Promotion of Science 20K07410Japan Society for the Promotion of Science 23K06446
6 · The paper itself

Abstract

Evidence for the tumour-supporting capacities of the tumour stroma has accumulated rapidly in colorectal cancer (CRC). Tumour stroma is composed of heterogeneous cells and components including cancer-associated fibroblasts (CAFs), small vessels, immune cells, and extracellular matrix proteins. The present study examined the characteristics of CAFs and collagen, major components of cancer stroma, by immunohistochemistry and Sirius red staining. The expression status of five independent CAF-related or stromal markers, decorin (DCN), fibroblast activation protein (FAP), podoplanin (PDPN), alpha-smooth muscle actin (ACTA2), and collagen, and their association with clinicopathological features and clinical outcomes were analysed. Patients with DCN-high tumours had a significantly worse 5-year survival rate (57.3% versus 79.0%; p = 0.044). Furthermore, hierarchical clustering analyses for these five markers identified three groups that showed specific characteristics: a solid group (cancer cell-rich, DCN

Indexed as

Biomarkers, TumorCancer-Associated FibroblastsColorectal NeoplasmsAdultAgedAged, 80 and overCluster AnalysisDecorinFemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMembrane GlycoproteinsMiddle AgedPodoplaninBiomarkers, TumorDCN protein, humanDecorinMembrane GlycoproteinsPDPN protein, humanPodoplanincancer‐associated fibroblasts (CAFs)colorectal cancer (CRC)decorin (DCN)hierarchical clustering analysisimmunohistochemistrypodoplanin (PDPN)

Identifiers

PMID38890810
PMCPMC11187867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.