Evidence map›Paper›PMID 38890728›Full record

ArticleStatistics in medicine2024

Sensitivity analysis for principal ignorability violation in estimating complier and noncomplier average causal effects.

Trang Quynh Nguyen, Elizabeth A Stuart, Daniel O Scharfstein, Elizabeth L Ogburn

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Article in Statistics in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Trang Quynh NguyenDepartment of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland.ORCID 0000-0003-1653-5491
Elizabeth A StuartDepartment of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland.
Daniel O ScharfsteinDivision of Biostatistics, Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, Utah.
Elizabeth L OgburnDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Funding

ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Causal mediation methods for studying mechanisms in mental healthR01MH115487 · NIMH · JOHNS HOPKINS UNIVERSITY · PI STUART, ELIZABETH A. · 2018 to 2021
$1.3M
Causal mediation analysis in mental health with mediator missingnessR03MH128634 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NGUYEN, TRANG QUYNH · 2022 to 2023
$164k
NIH HHS U24 OD023382NIH HHS U24OD023382NIMH NIH HHS R01 MH115487NIMH NIH HHS R01MH115487NIMH NIH HHS R03 MH128634NIMH NIH HHS R03MH128634Office of Naval Research N00014-21-1-2820
6 · The paper itself

Abstract

An important strategy for identifying principal causal effects (popular estimands in settings with noncompliance) is to invoke the principal ignorability (PI) assumption. As PI is untestable, it is important to gauge how sensitive effect estimates are to its violation. We focus on this task for the common one-sided noncompliance setting where there are two principal strata, compliers and noncompliers. Under PI, compliers and noncompliers share the same outcome-mean-given-covariates function under the control condition. For sensitivity analysis, we allow this function to differ between compliers and noncompliers in several ways, indexed by an odds ratio, a generalized odds ratio, a mean ratio, or a standardized mean difference sensitivity parameter. We tailor sensitivity analysis techniques (with any sensitivity parameter choice) to several types of PI-based main analysis methods, including outcome regression, influence function (IF) based and weighting methods. We discuss range selection for the sensitivity parameter. We illustrate the sensitivity analyses with several outcome types from the JOBS II study. This application estimates nuisance functions parametrically - for simplicity and accessibility. In addition, we establish rate conditions on nonparametric nuisance estimation for IF-based estimators to be asymptotically normal - with a view to inform nonparametric inference.

Indexed as

CausalityComputer SimulationData Interpretation, StatisticalHumansModels, StatisticalOdds RatioPatient Compliancecomplier average causal effectprincipal ignorabilityprincipal stratificationsensitivity analysis

Identifiers

PMID38890728
PMCPMC11995412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.