Evidence map›Paper›PMID 38890605›Full record

ArticleBMC musculoskeletal disorders2024

Low muscle density in children with osteogenesis imperfecta using opportunistic low-dose chest CT: a case-control study.

Yi Yuan, Yun-Feng Xu, Chao Feng, Yan-Dong Liu, Wen-Shuang Zhang, Peng-Ju Huang, Kang-Kang Ma, Feng-Yun Zhou, Zi-Tong Cheng, Zheng Yang and 2 more

Abstract read
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In one paragraph

Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yi Yuan *Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Yun-Feng Xu *Department of Pediatric Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Chao FengDepartment of Pediatric Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Yan-Dong LiuDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Wen-Shuang ZhangDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Peng-Ju HuangDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Kang-Kang MaDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Feng-Yun ZhouDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Zi-Tong ChengDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.
Zheng Yang *Department of Pediatric Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China. 117228569@163.com.
Ling Wang *Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China. doctorwl@bjmu.edu.cn.
Xiao-Guang ChengDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics, No. 31, Xinjiekou East Street, Beijing, 100035, China.

Funding

Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZYLX202107Beijing Hospitals Authority Youth Programme QML20200402Beijing Municipal Health Commission BJRITO-RDP-2024Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes JYY2023-8The National Natural Science Foundation of China 82371957
6 · The paper itself

Abstract

backgroundThe aim of the study was to investigate the muscle differences in children with osteogenesis imperfecta (OI) using opportunistic low-dose chest CT and to compare different methods for the segmentation of muscle in children.

methodsThis single center retrospective study enrolled children with OI and controls undergoing opportunistic low-dose chest CT obtained during the COVID pandemic. From the CT images, muscle size (cross-sectional area) and density (mean Hounsfield Units [HU]) of the trunk muscles were measured at the mid-T4 and the mid-T10 level using two methods, the fixed thresholds and the Gaussian mixture model. The Bland-Altman method was also used to compute the strength of agreement between two methods. Comparison of muscle results between OI and controls were analyzed with Student t tests.

results20 children with OI (mean age, 9.1 ± 3.3 years, 15 males) and 40 age- and sex-matched controls were enrolled. Mean differences between two methods were good. Children with OI had lower T4 and T10 muscle density than controls measured by the fixed thresholds (41.2 HU vs. 48.0 HU, p < 0.01; 37.3 HU vs. 45.9 HU, p < 0.01). However, children with OI had lower T4 muscle size, T4 muscle density, T10 muscle size and T10 muscle density than controls measured by the Gaussian mixture model (110.9 vs. 127.2 cm

conclusionsChildren with OI had lower trunk muscle density indicating that OI might also impair muscle quality. Moreover, the fixed thresholds may not be suitable for segmentation of muscle in children.

Indexed as

Muscle, SkeletalOsteogenesis ImperfectaTomography, X-Ray ComputedAdolescentCase-Control StudiesChildChild, PreschoolCOVID-19FemaleHumansMaleRadiation DosageRetrospective StudiesChildComputed tomographyMusclesOsteogenesis imperfecta

Identifiers

PMID38890605
PMCPMC11184700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.