Evidence map›Paper›PMID 38890481›Full record

ArticleCommunications biology2024

Membrane depolarization mediates both the inhibition of neural activity and cell-type-differences in response to high-frequency stimulation.

Jae-Ik Lee, Paul Werginz, Tatiana Kameneva, Maesoon Im, Shelley I Fried

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Article
  6. Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jae-Ik LeeDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. jaeikjq@gmail.com.ORCID 0000-0002-9006-3405
Paul WerginzDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tatiana KamenevaSchool of Science, Computing, and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC, Australia.ORCID 0000-0003-0081-8569
Maesoon ImBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, South Korea.
Shelley I FriedDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6456-8656

Funding

Investigating the Response of CNS Neurons to Electric and Magnetic StimulationR01NS110575 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2019 to 2023
$3.4M
Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) FWF P35488Austrian Science Fund FWF P 35488National Research Foundation of Korea (NRF) 2022M3E5E8017395NINDS NIH HHS R01 NS110575United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) VR170089U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01- NS110575
6 · The paper itself

Abstract

Neuromodulation using high frequency (>1 kHz) electric stimulation (HFS) enables preferential activation or inhibition of individual neural types, offering the possibility of more effective treatments across a broad spectrum of neurological diseases. To improve effectiveness, it is important to better understand the mechanisms governing activation and inhibition with HFS so that selectivity can be optimized. In this study, we measure the membrane potential (V

Indexed as

Electric StimulationMembrane PotentialsRetinal Ganglion CellsAction PotentialsAnimalsRats

Identifiers

PMID38890481
PMCPMC11189419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.