ArticleNature methods2024
Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution.
Article in Nature methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Label-free volumetric refractive-index imaging of fibrillar collagen architecture, assembly, and cell-associated remodeling.bioRxiv : the preprint server for biology · 2026Article
- Measurement of the absolute value of the optical birefringence of myelin in primate brain tissue.Neurophotonics · 2026Article
- Article
- Reconstructing Three-Dimensional Optical Anisotropy with Tomographic Müller-Polarimetric Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mantis: High-throughput 4D imaging and analysis of the molecular and physical architecture of cells.PNAS nexus · 2024Article
- Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
15 authors.
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Abstract
The dry mass and the orientation of biomolecules can be imaged without a label by measuring their permittivity tensor (PT), which describes how biomolecules affect the phase and polarization of light. Three-dimensional (3D) imaging of PT has been challenging. We present a label-free computational microscopy technique, PT imaging (PTI), for the 3D measurement of PT. PTI encodes the invisible PT into images using oblique illumination, polarization-sensitive detection and volumetric sampling. PT is decoded from the data with a vectorial imaging model and a multi-channel inverse algorithm, assuming uniaxial symmetry in each voxel. We demonstrate high-resolution imaging of PT of isotropic beads, anisotropic glass targets, mouse brain tissue, infected cells and histology slides. PTI outperforms previous label-free imaging techniques such as vector tomography, ptychography and light-field imaging in resolving the 3D orientation and symmetry of organelles, cells and tissue. We provide open-source software and modular hardware to enable the adoption of the method.
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