Evidence map›Paper›PMID 38890390›Full record

ArticleScientific reports2024

Transcriptomic profiling highlights cell proliferation in the progression of experimental pulmonary hypertension in rats.

Ang Luo, Rongrong Hao, Xia Zhou, Yangfan Jia, Changlei Bao, Lei Yang, Lirong Zhou, Chenxin Gu, Ankit A Desai, Haiyang Tang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The right time, the right cell: the potential for precision senotherapy in pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ang LuoCollege of Veterinary Medicine, Northwest A and F University, Yangling, 712100, China. luoang369@nwafu.edu.cn.
Rongrong HaoCollege of Veterinary Medicine, Northwest A and F University, Yangling, 712100, China.
Xia ZhouCollege of Veterinary Medicine, Northwest A and F University, Yangling, 712100, China.
Yangfan JiaInstitute of Zoology, Guangdong Academy of Sciences, Guangzhou, 510260, China.
Changlei BaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Lei YangCollege of Veterinary Medicine, Northwest A and F University, Yangling, 712100, China.
Lirong ZhouCollege of Veterinary Medicine, Northwest A and F University, Yangling, 712100, China.
Chenxin GuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Ankit A DesaiDepartment of Medicine, Indiana University, Indianapolis, IN, 46202, USA.
Haiyang TangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. tanghy2008@yahoo.com.
Ai-Ai ChuDivision of Echocardiography, Department of Cardiology, Gansu Provincial Hospital, Lanzhou, 730000, China. aiaichu@126.com.

Funding

National Key Research and Development Program of China 2019YFE0119400Natural Science Foundation of China 82000054, 82370060, 82170057 and 82300074Natural Science Foundation of Gansu Province 21JR7RA604Open Project of State Key Laboratory of Respiratory Disease SKLRD-OP-202114/202301/202403
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remolding and occlusion, leading to the elevated pulmonary arterial pressures, right ventricular hypertrophy, and eventual heart failure if left untreated. Understanding the molecular mechanisms underlying the development and progression of pulmonary hypertension (PH) is crucial for devising efficient therapeutic approaches for the disease. Lung homogenates were collected weekly and underwent RNA-sequencing in the monocrotaline (MCT)-induced PH rat model to explore genes associated with PH progression. Statistical analyses revealed 1038, 1244, and 3125 significantly altered genes (P < 0.05, abs (log

Indexed as

Cell ProliferationDisease Models, AnimalDisease ProgressionGene Expression ProfilingHypertension, PulmonaryMonocrotalineAnimalsLungMaleRatsRats, Sprague-DawleyTranscriptomeMonocrotalineCell proliferationPulmonary arterial hypertensionRNA sequencing

Identifiers

PMID38890390
PMCPMC11189536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.