Evidence map›Paper›PMID 38890202›Full record

Observational studyBreast cancer (Tokyo, Japan)2024

Prognosis of isolated locoregional recurrence after early breast cancer with immediate breast reconstruction surgery: a retrospective multi‑institutional study.

Hirohito Seki, Akiko Ogiya, Naomi Nagura, Ayaka Shimo, Kazutaka Narui, Shinsuke Sasada, Makoto Ishitobi, Hiroko Nogi, Naoto Kondo, Teruhisa Sakurai and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Breast cancer (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Hirohito SekiDepartment of Breast Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-city, Tokyo, 181-8611, Japan. hirohito.seki@gmail.com.ORCID http://orcid.org/0000-0002-3211-4817
Akiko OgiyaDepartment of Breast Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Naomi NaguraDepartment of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan.
Ayaka ShimoDepartment of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Kazutaka NaruiDepartment of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Shinsuke SasadaDepartment of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Makoto IshitobiDepartment of Breast Surgery, Mie University School of Medicine, Mie, Japan.
Hiroko NogiDepartment of Breast and Endocrine Surgery, Jikei University School of Medicine, Tokyo, Japan.
Naoto KondoDepartment of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Teruhisa SakuraiSakurai Breast Clinic, Wakayama, Japan.
Chikako YamauchiDepartment of Radiation Oncology, Shiga General Hospital, Shiga, Japan.
Hiroki MoriDepartment of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Miho SaigaDepartment of Plastic Surgery, Okayama University Hospital, Okayama, Japan.
Naoki NiikuraDepartment of Breast Oncology, Tokai University School of Medicine, Kanagawa, Japan.
Tadahiko ShienDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognosis in patients with breast cancer with isolated locoregional recurrence (ILRR) without simultaneous distant metastases after immediate breast reconstruction (IBR) remains unknown. We aimed to investigate the prognosis in this patient population.

methodsThis multi-institutional retrospective observational study evaluated 3295 patients with primary breast cancer who underwent IBR at 12 Japanese medical facilities between January 1, 2008 and December 31, 2016. The outcome measures were the prognostic factors for ILRR after IBR, 5-year distant metastasis-free interval (DMFI), and 5-year overall survival (OS).

resultsMastectomy or skin-sparing mastectomy was performed in 3295 patients. ILRR occurred in 70 patients, and the median observation period from ILRR diagnosis was 39.3 months. Of the 70 patients, 9 (12.9%) had axillary lymph node recurrence (ALNR) at the time of ILRR diagnosis. The 5-year DMFI and OS rates after ILRR were 92.4% and 91.2%, respectively. Pathological lymph node metastasis at primary surgery (P = 0.041) and ALNR (P = 0.022) at ILRR were significantly associated with DMFI in the univariate analysis. ALNR was the only independent prognostic factor in the multivariate analysis (P = 0.041). Post-mastectomy radiation therapy (PMRT; P = 0.022) and ALNR (P = 0.043) were significantly associated with OS in the univariate analysis, and both PMRT (P = 0.010) and ALNR (P = 0.028) were independent prognostic factors in the multivariate analysis for OS.

conclusionsAlthough patients with breast cancer who had ILRR after IBR have favorable prognosis, ALNR may lead to poor prognosis. To the best of our knowledge, this study is the first to report the prognosis of these patients.

Indexed as

Breast NeoplasmsLymphatic MetastasisMammaplastyNeoplasm Recurrence, LocalAdultAgedFemaleHumansMastectomyMiddle AgedPrognosisRetrospective StudiesBreast cancerImmediate breast reconstruction surgeryIsolated locoregional recurrencePrognosisSkin-sparing mastectomy

Identifiers

PMID38890202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.