Evidence map›Paper›PMID 38890176›Full record

ArticleAnnals of hematology2024

Thrombopoietin receptor agonists regulate myeloid-derived suppressor cell-mediated immunomodulatory effects in ITP.

Yingqiao Zhu, Yan Wang, Yue Zhao, Dan Liu, Xiaoyu Wang, Lijun Zhu, Juan Tong, Na Zhao, Changcheng Zheng

Abstract read
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In one paragraph

Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingqiao ZhuDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Yan WangDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Yue ZhaoDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Dan LiuDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Xiaoyu WangDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Lijun ZhuDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Juan TongDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Na ZhaoDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China.
Changcheng ZhengDepartment of Hematology, Division of Life Sciences and Medicine, the First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road No 17, Hefei, 230001, China. zhengchch1123@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TPO receptor agonists (TPO-RAs) are a class of clinical second-line regimens for the treatment of primary immune thrombocytopenia (ITP). It can promote megakaryocyte maturation and increase platelet production, but its effect on immunosuppressive cells in patients with ITP has not been explored. Sixty-two ITP patients and 34 healthy controls (HCs) were included in this study. The proportion and functions of myeloid-derived immunosuppressive cells (MDSCs) in ITP patients and HCs were investigated. We found that the proportion and function of MDSCs in ITP patients treated with TPO-RAs were significantly higher than those treated with glucocorticoids (GCs), which was correlated with the clinical efficacy. The proportion and function of cytotoxic Th1 cells and CD8

Indexed as

ImmunomodulationPurpura, Thrombocytopenic, IdiopathicReceptors, ThrombopoietinAdultGene Expression RegulationHumansMaleMiddle AgedMyeloid-Derived Suppressor CellsT-LymphocytesMPL protein, humanReceptors, ThrombopoietinImmune thrombocytopeniaImmunosuppressive functionMyeloid-derived suppressor cellThrombopoietin receptor agonistsTreg cells

Identifiers

PMID38890176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.