Evidence map›Paper›PMID 38890088›Full record

ArticleJournal of cardiothoracic and vascular anesthesia2024

The Association of Oxygen Delivery and Transfusion on Cardiopulmonary Bypass with Acute Kidney Injury.

Milo Engoren, Allison Janda, Michael Heung, David Sturmer, Donald S Likosky, Robert B Hawkins, Chi Chi Do-Nguyen, Michael Mathis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic and vascular anesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milo EngorenDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI. Electronic address: engorenm@med.umich.edu.
Allison JandaDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI.
Michael HeungDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
David SturmerDepartment of Perfusion, University of Michigan, Ann Arbor, MI.
Donald S LikoskyDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI.
Robert B HawkinsDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI.
Chi Chi Do-NguyenDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI.
Michael MathisDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI.

Funding

PHEnylephrine versus NOrepinephrine in Major NONcardiac surgery (PHENOMeNON): Foundational Studies for a Pragmatic Randomized Clinical Trial.K23HL166685 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Allison Mary Janda · 2023 to 2026
$689k
NHLBI NIH HHS K23 HL166685
6 · The paper itself

Abstract

objectivesTo estimate whether the association of transfusion and acute kidney injury (AKI) has a threshold of oxygen delivery below which transfusion is beneficial but above which it is harmful.

designRetrospective study

settingCardiovascular operating room and intensive care unit

participantsPatients undergoing cardiac surgery with continuous oxygen delivery monitoring during cardiopulmonary bypass

interventionsNone MEASUREMENTS AND MAIN

resultsLogistic regression was used to estimate the associations between oxygen delivery (mean, cumulative deficit, and bands of oxygen delivery), transfusion, and their interaction and AKI. A subgroup analysis of transfused and nontransfused patients with exact matching on cumulative oxygen deficit and time on bypass with adjustment for propensity to receive a transfusion using logistic regression. Nine hundred ninety-one of 4,203 patients developed AKI within 7 days. After adjustment for confounders, lower mean oxygen delivery (odds ratio [OR], 0.968; 95% confidence interval [CI], 0.949-0.988; p = 0.002) and transfusions (OR, 1.442; 95% CI, 1.077, 1.932; p = 0.014) were associated with increased odds of AKI by 7 days. As oxygen delivery decreased, the risk of AKI increased, with the slope of the OR steeper at <160 mL/m

conclusionsWe found a nonlinear relationship between oxygen delivery and AKI. We found no level of oxygen delivery at which transfusion was associated with a decreased risk of AKI.

Indexed as

Acute Kidney InjuryCardiopulmonary BypassOxygenAgedBlood TransfusionFemaleHumansMaleMiddle AgedRetrospective StudiesOxygenacute kidney injurycardiopulmonary bypassoxygen deliveryred cell transfusion

Identifiers

PMID38890088
PMCPMC11638857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.