ArticleAmerican journal of perinatology2025
Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth.
Namasivayam Ambalavanan, C Michael Cotten, Stephen W Erickson, Ravi Mathur, Dara Torgerson, Philip L Ballard, Eunice Kennedy Shriver NICHD Neonatal Research Network and the TOLSURF Study Group
Abstract read
In one paragraphArticle in American journal of perinatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-0731-9092 C Michael CottenDepartment of Pediatrics, Duke University, Durham, North Carolina.
Stephen W EricksonGenomics Research Center, RTI International, Research Triangle Park, North Carolina.
Ravi MathurGenomics Research Center, RTI International, Research Triangle Park, North Carolina.
Dara TorgersonDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Philip L BallardDepartment of Pediatrics, University of California San Francisco, San Francisco, California.
Eunice Kennedy Shriver NICHD Neonatal Research Network and the TOLSURF Study Group
Funding
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MNeonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2MNeonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2MXOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI PARSONNET, JULIE · 1985 to 2008
$32.4MZUNI KIDNEY PROJECT STUDY I--POPULATION BASED SURVEY OF RENAL DISEASEM01RR000997 · NCRR · UNIVERSITY OF NEW MEXICO · PI MERTZ, GREGORY JAMES · 1985 to 2010
$30.0MZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI STORNIOLO, ANNA · 1985 to 2008
$25.5MZevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6MZosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2MData Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8MX LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI QUYYUMI, ARSHED A · 1985 to 2007
$21.3MXU 40468 IN HYPERCHOLESTEROLEMIAM01RR000633 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI RAO, UMA · 1985 to 2007
$21.0MNCATS NIH HHS UL1 TR000004NCRR NIH HHS M01 RR000030NCRR NIH HHS M01 RR000032NCRR NIH HHS M01 RR000039NCRR NIH HHS M01 RR000070NCRR NIH HHS M01 RR000080NCRR NIH HHS M01 RR000633NCRR NIH HHS M01 RR000750NCRR NIH HHS M01 RR000997NCRR NIH HHS M01 RR006022NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR016587NHGRI NIH HHS U01 HG004423NHLBI NIH HHS U01 HL094338NHLBI NIH HHS U01 HL094355NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD021410NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053109NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492
6 · The paper itselfAbstract
objectiveExtremely preterm infants are at high risk of neonatal mortality and morbidity. Extreme preterm birth (PTB) may result from spontaneous preterm labor or preterm premature rupture of membranes or may be indicated due to preeclampsia, eclampsia, hypertension, or other causes. Our objective was to identify single nucleotide polymorphisms (SNPs) and biological pathways associated with spontaneous versus indicated extreme PTB using the neonatal genome. STUDY
designWe evaluated 523 spontaneous births and 134 indicated births weighing 401 to 1,000 g at birth from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Genomics dataset by genome-wide association study (GWAS) and pathway analysis. The TOLSURF cohort was used to replicate the results.
resultsIn the NRN GWAS, no statistically significant results were found, although the Manhattan plot showed one almost significant peak (rs60854043 on chromosome 14 at
conclusionGenomic differences are seen between infants born by spontaneous versus indicated extreme PTB. Due to the limited sample size, there is a need for larger studies. KEY POINTS: · Genomic differences are seen between infants born by spontaneous versus indicated very PTB.. · Future studies with large sample sizes evaluating extreme PTB are necessary.. · Spontaneous PTB is more common than indicated extreme PTB..
Indexed as
Genome-Wide Association StudyInfant, Extremely PrematurePolymorphism, Single NucleotidePremature BirthAdultFemaleGenomicsGestational AgeHumansInfant, NewbornMalePregnancyPremature Rupture of Fetal Membranes
Identifiers
PMID38889886
PMCPMC11693484
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