Evidence map›Paper›PMID 38889880›Full record

SynthesisJournal of substance use and addiction treatment2024

A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders.

William R Nardi, Patrick Kelly, Alexandra Roy, Sara Becker, Judson Brewer, Shufang Sun

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of substance use and addiction treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Do posttreatment increases in social recovery capital mediate the relationship between lower internalizing symptoms and less substance use?Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William R NardiDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Mindfulness Center, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA. Electronic address: William_nardi@brown.edu.
Patrick KellyDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA.
Alexandra RoyDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Mindfulness Center, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA.
Sara BeckerCenter for Dissemination and Implementation Science, Northwestern University Feinberg School of Medicine, 663 N St. Clair Street, Chicago, IL 60611, USA.
Judson BrewerDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Mindfulness Center, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI 02903, USA.
Shufang SunDepartment of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Mindfulness Center, Brown University School of Public Health, 121 South Main Street, Providence, RI 02903, USA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI 02903, USA.

Funding

Developing an adjunctive mobile application for co-morbid substance use and anxiety disorders: comprehensive user experience testing of the Unwinding Anxiety applicationF31DA055463 · NIDA · BROWN UNIVERSITY · PI NARDI, WILLIAM · 2022 to 2024
$143k
NIDA NIH HHS F31 DA055463
6 · The paper itself

Abstract

BACKGROUND &

aimsAnxiety and substance use disorders are highly comorbid and represent two of the leading causes of disease burden globally. Psychosocial interventions are important treatment options for people with co-occurring anxiety and substance use (A-SUD). To date, few reviews have assessed the efficacy of psychosocial treatments for patients with A-SUD. This systematic review and meta-analysis aims to synthesize this literature and assess the efficacy of psychosocial interventions among patients with A-SUD.

methodsWe searched all relevant records published until March 2023 in Medline, EMBASE, PsycINFO, CINAHL and Google Scholar. Two authors extracted and reconciled relevant data and assessed risk of bias. Random effects models were used to calculate effect sizes using Hedges' g for post treatment and follow-up time points. Main outcomes of the review were anxiety, alcohol use, and use of other substances. We examined effects on depression as a secondary outcome since it commonly co-occurs with A-SUD.

resultsPsychosocial interventions for co-occurring A-SUD showed moderate effects on anxiety (g = 0.44), alcohol (Hedges' g = 0.29), and other substance use (g = 0.38) at post intervention. Large effects were observed on depression (g = 0.88) at post intervention with high heterogeneity. These effects were maintained at follow-up for anxiety (Hedges' g = 0.38), other substances (g = 0.44), and depression (g = 0.50). Moderation analyses for demographic factors, intervention characteristics, community level factors, anxiety reduction, and alcohol use reduction, were non-significant.

conclusionsThe current meta-analysis investigated the effects of psychosocial interventions on patients with anxiety and co-occurring SUD. The analyses indicated promising moderate-sized effects of treatment on anxiety, alcohol, all other drug use, and depression. The findings point to important avenues for psychosocial treatment while highlighting critical gaps in knowledge to be addressed in future research.

Indexed as

AnxietyPsychosocial InterventionSubstance-Related DisordersComorbidityDepressionHumansAddictionAnxietyMental healthMeta-analysisPsychosocialSubstance use

Identifiers

PMID38889880
PMCPMC11347123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.