Evidence map›Paper›PMID 38889798›Full record

ArticleEuropean heart journal2024

Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study.

Donghao Lu, Unnur A Valdimarsdóttir, Dang Wei, Yufeng Chen, Ole A Andreassen, Fang Fang, Krisztina D László, Emma Bränn

Abstract read
In one paragraph

Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
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  6. Article
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  12. Mood disorders and peripartum cardiomyopathy.Pregnancy (Hoboken, N.J.) · 2025
    Article
  13. Article
  14. Article
  15. Tailoring cardiovascular risk prediction to females.The Journal of endocrinology · 2025
    Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Donghao LuInstitute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.ORCID 0000-0002-4186-8661
Unnur A ValdimarsdóttirInstitute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.ORCID 0000-0001-5382-946X
Dang WeiInstitute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.ORCID 0000-0003-1287-7929
Yufeng ChenInstitute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Fang FangInstitute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.ORCID 0000-0002-3310-6456
Krisztina D LászlóDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Emma BrännInstitute of Environmental Medicine, Unit of Integrative Epidemiology, Karolinska Institutet, Nobels väg 13, 17177 Stockholm, Sweden.ORCID 0000-0001-9664-7973

Funding

European Horizon 2020Icelandic Research Fund 218274-051Karolinska Institutet's Research Foundation Grant 2022-01548Karolinska Institutet Strategic Research Area in Epidemiology and BiostatisticsSwedish Research Council 2020-01003Swedish Research Council for Health, Working Life and Welfare 2020-00971
6 · The paper itself

Abstract

BACKGROUND AND

aimsIncreasing evidence suggests that some reproductive factors/hazards are associated with a future risk of cardiovascular disease (CVD) in women. While major (non-perinatal) depression has consistently been associated with CVD, the long-term risk of CVD after perinatal depression (PND) is largely unknown.

methodsA nationwide population-based matched cohort study involving 55 539 women diagnosed with PND during 2001-14 in Sweden and 545 567 unaffected women individually matched on age and year of conception/delivery was conducted. All women were followed up to 2020. Perinatal depression and CVD were identified from Swedish national health registers. Using multivariable Cox models, hazard ratios (HR) of any and type-specific CVD according to PND were estimated.

resultsThe mean age at the PND diagnosis was 30.8 [standard deviation (SD) 5.6] years. During the follow-up of up to 20 years (mean 10.4, SD 3.6), 3533 (6.4%) women with PND (expected number 2077) and 20 202 (3.7%) unaffected women developed CVD. Compared with matched unaffected women, women with PND had a 36% higher risk of developing CVD [adjusted HR = 1.36, 95% confidence interval (CI): 1.31-1.42], while compared with their sisters, women with PND had a 20% higher risk of CVD (adjusted HR = 1.20, 95% CI 1.07-1.34). The results were most pronounced in women without a history of psychiatric disorder (P for interaction < .001). The association was observed for all CVD subtypes, with the highest HR in the case of hypertensive disease (HR = 1.50, 95% CI: 1.41-1.60), ischaemic heart disease (HR = 1.37, 95% CI: 1.13-1.65), and heart failure (HR 1.36, 95% CI: 1.06-1.74).

conclusionsWomen with PND are at higher risk of CVD in middle adulthood. Reproductive history, including PND, should be considered in CVD risk assessments of women.

Indexed as

Cardiovascular DiseasesAdultDepressionFemaleHumansPregnancyPregnancy ComplicationsRisk FactorsSwedenCardiovascular diseaseHeart failureIschaemic heart diseasePerinatal depressionPostpartum depressionStroke

Identifiers

PMID38889798
PMCPMC11328867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.