Evidence map›Paper›PMID 38889702›Full record

Observational studyNeonatology2024

Air or Oxygen for Infant Resuscitation: A Prospective Cohort Study of Moderate-Late Preterm Infants Requiring Delivery Room Resuscitation.

James X Sotiropoulos, Sheeba Binoy, Thy A N Pham, Kylie Yates, Catherine L Allgood, Ansar Kunjunju, Mark Tracy, John Smyth, Ju Lee Oei

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neonatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James X SotiropoulosDepartment of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia, james.sotiropoulos@sydney.edu.au.
Sheeba BinoyDepartment of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia.
Thy A N PhamDepartment of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia.
Kylie YatesDepartment of Paediatrics, St George Hospital, Kogarah, New South Wales, Australia.
Catherine L AllgoodDepartment of Paediatrics, Campbelltown Hospital, University of Western Sydney School of Medicine, Campbelltown, New South Wales, Australia.
Ansar KunjunjuDepartment of Newborn Care, The Wollongong Hospital, Wollongong, New South Wales, Australia.
Mark TracyDepartment of Newborn Care, Westmead Hospital, Westmead, New South Wales, Australia.
John SmythDepartment of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia.
Ju Lee OeiDepartment of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDue to concerns of oxidative stress and injury, most clinicians currently use lower levels of fractional inspired oxygen (FiO2, 0.21-0.3) to initiate respiratory support for moderate to late preterm (MLPT, 32-36 weeks gestation) infants at birth. Whether this practice achieves recommended oxygen saturation (SpO2) targets is unknown.

methodsWe aimed to determine SpO2 trajectories of MLPT infants requiring respiratory support at birth. We conducted a prospective, opportunistic, observational study with consent waiver. Preductal SpO2 readings were obtained during the first 10 min of life from infants between 32 and 36 weeks gestation requiring respiratory support in the delivery room. Primary outcome was reaching a minimum SpO2 80% at 5 min of life. The study was prospectively registered (ACTRN12620001252909).

resultsA total of 76 eligible infants were recruited between February 2021 and March 2022 from 5 hospitals in Australia. Most (n = 58, 76%) had respiratory support initiated with FiO2 0.21 (range 0.21-1.0) using CPAP (92%). Median SpO2 at 5 min was 81% (interquartile range [IQR] 67-90) and 93% (IQR 86-96) at 10 min. At 5 min, 18/43 (42%) infants had SpO2 below 80% and only 8/43 (19%) reached SpO2 80-85%.

conclusionsMany MLPT infants requiring respiratory support do not achieve recommended SpO2 targets. In very preterm infants, SpO2 <80% at 5 min of life increases risk of death, intraventricular haemorrhage, and neurodevelopmental impairment. The implications on this practice on the health outcomes of MLPT infants are unclear and require further research.

Indexed as

Delivery RoomsGestational AgeInfant, PrematureOxygenOxygen Inhalation TherapyOxygen SaturationResuscitationAustraliaContinuous Positive Airway PressureFemaleHumansInfant, NewbornMaleProspective StudiesRespiratory Distress Syndrome, NewbornOxygenNeonatal resuscitationOxygenOxygen saturationPreterm birth

Identifiers

PMID38889702
PMCPMC11633904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.