Evidence map›Paper›PMID 38889679›Full record

ArticleCurrent biology : CB2024

RNA: De-silencing to the rescue.

James P Held, Maulik R Patel

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James P HeldDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
Maulik R PatelDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Evolutionary Studies, Vanderbilt University, VU Box #34-1634, Nashville, TN 37232, USA; Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Quantitative Systems Biology Center, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: maulik.r.patel@vanderbilt.edu.

Funding

Mechanisms of mutant mitochondrial genome modulationR35GM145378 · NIGMS · VANDERBILT UNIVERSITY · PI MAULIK R PATEL · 2022 to 2026
$2.4M
NIGMS NIH HHS R35 GM145378
6 · The paper itself

Abstract

The fate of transcribed RNA dictates cellular function. A new study finds that mutations in specific RNA processing machinery genes result in de-silencing of a transcript encoding a subunit of the mitochondrial electron transport chain and rescue of a mitochondrial respiratory complex I defect.

Indexed as

Electron Transport Complex IAnimalsGene SilencingMitochondriaMutationElectron Transport Complex I

Identifiers

PMID38889679
PMCPMC13242885

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.