ArticleNeurology2024
Associations of Cerebral Small Vessel Disease and Chronic Kidney Disease in Patients With Acute Intracerebral Hemorrhage: A Cross-Sectional Study.
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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- Neuroimaging Markers Associated With Recurrent Stroke in Intracerebral Hemorrhage and Atrial Fibrillation: Secondary Analysis of PRESTIGE-AF.Neurology · 2025Trial
- From Cognitive Impairment to Uremic Encephalopathy in Chronic Kidney Disease: A Proposed Pathophysiological Continuum.International journal of molecular sciences · 2026Review
- Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function.Neurology · 2026Article
- A latent genetic factor underlies multiple component phenotypes of cerebral small vessel disease.BMC neuroscience · 2026Article
- Mind the Gut: Cognitive Decline, Microbiota, and Nutrition-Related Modulators in Older Adults with Chronic Kidney Disease.Nutrients · 2026Review
- Sex differences in aetiology of intracerebral haemorrhage and associated small vessel disease patterns.European stroke journal · 2026Observational
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Island Sign on Computed Tomography Is Associated With Cerebral Amyloid Angiopathy in Patients With Intracerebral Hemorrhage.Journal of the American Heart Association · 2026Article
- Serum cystatin C levels are independently correlated with cognitive impairment in individuals with cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- Associations of chronic kidney disease with recurrent stroke in patients with intracerebral haemorrhage.European stroke journal · 2026Article
- Chronic kidney disease and cardiac remodeling potentiate cognitive impairment progression: disentangling the sex-specific cross talk of kidney-heart-brain axis.American journal of physiology. Heart and circulatory physiology · 2026Article
- Exploring the potential relationship between kidney disease index and cognitive dysfunction: a machine learning approach with NHANES data.BMC geriatrics · 2025Article
- Association of the difference between cystatin C- and creatinine-based estimated glomerular filtration rate with cerebral small vessel disease: A large prospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- CD2AP at the junction of nephropathy and Alzheimer's disease.Molecular neurodegeneration · 2025Review
- Associations of Cerebral Small Vessel Disease and Chronic Kidney Disease in Patients With Acute Ischemic Stroke.Journal of the American Heart Association · 2025Article
- Chronic kidney disease as a catalyst for cerebral microbleeds: understanding the underlying mechanisms and treatment approaches.Frontiers in medicine · 2025Review
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Authors and funding
15 authors.
Philip S NashFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0003-2428-1575
Simon Fandler-HöflerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0001-9043-0378
Gareth AmblerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0002-5322-7327
Wenpeng ZhangFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0001-8748-3962
Hatice OzkanFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0003-1656-4559
Martina LocatelliFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0002-5019-964X
Yang DuFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0002-0805-6282
Lena ObergottsbergerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.
Gerit WünschFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.
Hans Rolf JägerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0002-6403-4184
Christian EnzingerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0001-9764-7617
David C WheelerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.
Robert J SimisterFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0003-0578-6711
Thomas GattringerFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0002-6065-6576
David J WerringFrom the UCL Stroke Research Centre (P.S.N., S.F.-H., W.Z., H.O., M.L., Y.D., R.J.S., D.J.W.), Department of Brain Repair and Rehabilitation, and Comprehensive Stroke Service (P.S.N., H.O., R.J.S., D.J.W.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, UCL Queen Square Institute of Neurology, London, United Kingdom; Department of Neurology (S.F.-H., L.O., C.E., T.G.), Medical University of Graz, Austria; Department of Statistical Science (G.A.), University College London, United Kingdom; Institute for Medical Informatics (G.W.), Statistics and Documentation, Medical University of Graz, Austria; Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology; Department of Renal Medicine (D.C.W.), University College London, United Kingdom; and Division of Neuroradiology (T.G.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria.ORCID 0000-0003-2074-1861
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesChronic kidney disease (CKD) may be associated with the pathogenesis and phenotype of cerebral small vessel disease (SVD), which is the commonest cause of intracerebral hemorrhage (ICH). The purpose of this study was to investigate the associations of CKD with ICH neuroimaging phenotype, volume, and location, total burden of small vessel disease, and its individual components.
methodsIn 2 cohorts of consecutive patients with ICH evaluated with MRI, we investigated the frequency and severity of CKD based on established Kidney Disease Improving Global Outcomes criteria, requiring estimated glomerular filtration rate (eGFR) measurements <60 mL/min/1.73
resultsOf 875 patients (mean age 66 years, 42% female), 146 (16.7%) had CKD. After adjusting for age, sex, and comorbidities, patients with CKD had higher rates of mixed SVD than those with eGFR >60 (relative risk ratio 2.39, 95% CI 1.16-4.94, DISCUSSION: In patients with ICH, CKD was associated with SVD burden, a mixed SVD phenotype, and markers of arteriolosclerosis. Our findings indicate that CKD might independently contribute to the pathogenesis of arteriolosclerosis and mixed SVD, although we could not definitively account for the severity of shared risk factors. Longitudinal and experimental studies are, therefore, needed to investigate causal associations. Nevertheless, stroke clinicians should be aware of CKD as a potentially independent and modifiable risk factor of SVD.
Indexed as
Cerebral HemorrhageCerebral Small Vessel DiseasesMagnetic Resonance ImagingRenal Insufficiency, ChronicAgedAged, 80 and overCross-Sectional StudiesFemaleGlomerular Filtration RateHumansMaleMiddle Aged
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