Evidence map›Paper›PMID 38889367›Full record

ReviewMedical physics2024

Review of chemical models and applications in Geant4-DNA: Report from the ESA BioRad III Project.

Hoang Ngoc Tran, Jay Archer, Gérard Baldacchino, Jeremy M C Brown, Flore Chappuis, Giuseppe Antonio Pablo Cirrone, Laurent Desorgher, Naoki Dominguez, Serena Fattori, Susanna Guatelli and 10 more

Abstract readReview
In one paragraph

Review in Medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hoang Ngoc TranUniv. Bordeaux, CNRS, LP2I, UMR 5797, Gradignan, France.ORCID https://orcid.org/0000-0002-9243-6842
Jay ArcherCentre For Medical and Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.ORCID https://orcid.org/0009-0008-5248-5739
Gérard BaldacchinoUniversité Paris-Saclay, CEA, LIDYL, Gif-sur-Yvette, France.
Jeremy M C BrownOptical Sciences Centre, Department of Physics and Astronomy, School of Science, Swinburne University of Technology, Melbourne, Australia.
Flore ChappuisInstitute of Radiation Physics (IRA), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Giuseppe Antonio Pablo CirroneIstituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali del Sud (LNS), Catania, Italy.ORCID https://orcid.org/0000-0001-5733-9281
Laurent DesorgherInstitute of Radiation Physics (IRA), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Naoki DominguezDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-4410-1925
Serena FattoriIstituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali del Sud (LNS), Catania, Italy.ORCID https://orcid.org/0000-0002-9381-7620
Susanna GuatelliCentre For Medical and Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Vladimir IvantchenkoCERN, Geneva, Switzerland.
José-Ramos MéndezDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.
Petteri NieminenEuropean Space Agency, ESTEC, Noordwijk, The Netherlands.
Yann PerrotInstitut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France.
Dousatsu SakataCentre For Medical and Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Giovanni SantinEuropean Space Agency, ESTEC, Noordwijk, The Netherlands.
Wook-Geun ShinPhysics Division, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8622-1888
Carmen VillagrasaInstitut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France.
Sara ZeinUniv. Bordeaux, CNRS, LP2I, UMR 5797, Gradignan, France.
Sebastien IncertiUniv. Bordeaux, CNRS, LP2I, UMR 5797, Gradignan, France.ORCID https://orcid.org/0000-0002-0619-2053

Funding

TOPAS - nBio, a Monte Carlo tool for radiation biology researchR01CA187003 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2015 to 2024
$4.8M
Using experimentally-guided multi-scale modeling to determining the mechanism of FLASH tissue sparingR01CA266419 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2022 to 2025
$3.3M
ESA/BioRad3 4000132935/21/NL/CRSESA/BioRad3 NIH/NCI R01CA187003ESA/BioRad3 R01CA266419NCI NIH HHS R01 CA187003NCI NIH HHS R01 CA266419
6 · The paper itself

Abstract

A chemistry module has been implemented in Geant4-DNA since Geant4 version 10.1 to simulate the radiolysis of water after irradiation. It has been used in a number of applications, including the calculation of G-values and early DNA damage, allowing the comparison with experimental data. Since the first version, numerous modifications have been made to the module to improve the computational efficiency and extend the simulation to homogeneous kinetics in bulk solution. With these new developments, new applications have been proposed and released as Geant4 examples, showing how to use chemical processes and models. This work reviews the models implemented and application developments for modeling water radiolysis in Geant4-DNA as reported in the ESA BioRad III Project.

Indexed as

DNAModels, ChemicalDNA DamageMonte Carlo MethodSoftwareWaterDNAWaterGeant4‐DNAradiation chemistrywater radiolysis

Identifiers

PMID38889367
PMCPMC11489035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.