ReviewAmerican journal of respiratory and critical care medicine2024
Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers.
Review in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exhaled breath volatile organic compounds (VOCs) detection methods: GC-MS versus eNose in COPD diagnosis-a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- BreathSense: A Two-Stage Digital Framework for Student Stress Monitoring Using Personalized Breath-VOC Thresholding and In-the-Wild Validation.Behavioral sciences (Basel, Switzerland) · 2026Article
- The Role of the Respiratory Microbiome in Pneumonia.Clinics in chest medicine · 2026Review
- Real-Time Breath Diagnostics: Linking Molecular Pathways, Measurement Technologies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Exhaled breath volatiles for asthma diagnosis: discovery and validation in untreated but symptomatic patients.Scientific reports · 2026Article
- Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma.NPJ digital medicine · 2026Article
- Trained immunity in respiratory diseases: Mechanisms of action and intervention strategies.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Intermittent Hypoxia-Induced Inflammation and the Formation of Exhaled Volatile Organic Compound Profiles in Obstructive Sleep Apnea-Hypopnea Syndrome: A Narrative Review.Nature and science of sleep · 2026Review
- Breathomics in controlled asthma: identification of nonanoic and propanoic acids as volatile organic compounds.ERJ open research · 2025Article
- Circadian variability in breath volatiles is affected by the timing of inhaled corticosteroids in asthma.ERJ open research · 2025Article
- The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Breathomics: A Non-Invasive Approach for the Diagnosis of Breast Cancer.Bioengineering (Basel, Switzerland) · 2025Review
- Exhaled Breath Analysis Using a Novel Electronic Nose for Different Respiratory Disease Entities.Lung · 2025Article
- External Validation of Potential Breath Biomarkers for Asthma: A Step Forward Toward the Clinical Implementation of Breath Analysis.American journal of respiratory and critical care medicine · 2024Article
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13 authors.
Funding
Abstract
The exhaled breath represents an ideal matrix for noninvasive biomarker discovery, and exhaled metabolomics have the potential to be clinically useful in the era of precision medicine. In this concise translational review, we specifically address volatile organic compounds in the breath, with a view toward fulfilling the promise of these as actionable biomarkers, in particular, for lung diseases. We review the literature paying attention to seminal work linked to key milestones in breath research; discuss potential applications for breath biomarkers across disease areas and healthcare systems, including the perspectives of industry; and outline critical aspects of study design that will need to be considered for any pivotal research going forward if breath analysis is to provide robust validated biomarkers that meet the requirements for future clinical implementation.
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