Evidence map›Paper›PMID 38889334›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Genetically Designed Living Bacteria with Melanogenesis for Tumor-Specific Pigmentation and Therapeutic Intervention.

Liying Wang, Qi Wu, Qi Lyu, Dan Lu, Lehang Guo, Chao Zhong, Min Wang, Chang Liu, Bolin An, Huixiong Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liying WangDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, 301 Middle Yanchang Rd., Shanghai, 200072, P. R. China.
Qi WuDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, 301 Middle Yanchang Rd., Shanghai, 200072, P. R. China.
Qi LyuDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, 200032, P. R. China.
Dan LuDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, 200032, P. R. China.
Lehang GuoDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, 301 Middle Yanchang Rd., Shanghai, 200072, P. R. China.
Chao ZhongCenter for Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Min WangShanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Chang LiuDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, 301 Middle Yanchang Rd., Shanghai, 200072, P. R. China.
Bolin AnCenter for Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Huixiong XuDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, 200032, P. R. China.
Minfeng HuoDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, 301 Middle Yanchang Rd., Shanghai, 200072, P. R. China.ORCID 0000-0001-5717-1845

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2021A1515110175National Natural Science Foundation of China 32201105National Natural Science Foundation of China 82102048National Natural Science Foundation of China 82272135National Natural Science Foundation of China 82372121Natural Science Foundation of Shanghai 22ZR1448200Shanghai Rising-Star Program 23QA1407600Shanghai Rising-Star Program 23QA1409500
6 · The paper itself

Abstract

Visual observation and therapeutic intervention against tumors hold significant appeal for tumor treatment, particularly in meeting the demands of intraoperative navigation. From a clinical perspective, the naked-eye visualization of tumors provides a direct and convenient approach to identifying tumors and navigating during surgery. Nevertheless, there is an ongoing need to develop effective solutions in this frontier. Genetically engineered microorganisms are promising as living therapeutics for combatting malignant tumors, leveraging precise tumor targeting and versatile programmed functionalities. Here, genetically modified Escherichia coli (E. coli) MG1655 bacterial cells are introduced, called MelaBac cells, designed to express tyrosinase continuously. This bioengineered melanogenesis produces melanin capable of pigmenting both subcutaneous CT26 xenografts and chemically induced colorectal cancer (CRC). Additionally, MelaBac cells demonstrate the initiation of photonic hyperthermia therapy and immunotherapy against tumors, offering promising selective therapeutic interventions with high biocompatibility.

Indexed as

Escherichia coliMelaninsAnimalsCell Line, TumorColorectal NeoplasmsDisease Models, AnimalHumansImmunotherapyMelanogenesisMiceMonophenol MonooxygenasePigmentationMelaninsMonophenol Monooxygenasecolorectal cancergenetically engineered bacteriaimmunotherapyintratumoral pigmentationphotonic hyperthermia

Identifiers

PMID38889334
PMCPMC11336949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.