Evidence map›Paper›PMID 38889251›Full record

ArticleCirculation. Cardiovascular interventions2024

Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion.

Daniel J Friedman, Chengan Du, Sarah Zimmerman, Zhen Tan, Zhenqiu Lin, Sreekanth Vemulapalli, Andrzej S Kosinski, Jonathan P Piccini, Lucy Pereira, Karl E Minges and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular interventions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Left Atrial Appendage Occlusion in Cancer-Associated Atrial Fibrillation: Who, When, and How to Manage Antithrombotic Therapy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Daniel J FriedmanDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (D.J.F., S.V., A.S.K., J.P.P.).
Chengan DuCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).
Sarah ZimmermanCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).ORCID 0000-0003-0219-8498
Zhen TanCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).ORCID 0009-0004-1288-8526
Zhenqiu LinCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).
Sreekanth VemulapalliDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (D.J.F., S.V., A.S.K., J.P.P.).ORCID 0000-0003-1599-2957
Andrzej S KosinskiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (D.J.F., S.V., A.S.K., J.P.P.).ORCID 0000-0003-4151-5185
Jonathan P PicciniDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (D.J.F., S.V., A.S.K., J.P.P.).ORCID 0000-0003-0772-2404
Lucy PereiraCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).
Karl E MingesCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).ORCID 0000-0002-9063-8272
Kamil F FaridiCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).ORCID 0000-0002-9276-9110
Frederick A MasoudiAscension, St. Louis, MO (F.A.M.).ORCID 0000-0002-5681-6709
Jeptha P CurtisCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).ORCID 0000-0002-6872-0501
James V FreemanCenter for Outcomes Research and Evaluation, Yale New Haven Health, CT (C.D., S.Z., Z.T., Z.L., L.P., K.E.M., K.F.F., J.P.C., J.V.F.).ORCID 0000-0002-4614-6879

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)R01AG074185 · NIA · DUKE UNIVERSITY · PI MATHEW, JOSEPH P, PICCINI, JONATHAN PAUL · 2021 to 2025
$3.7M
Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R01HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2019 to 2022
$2.9M
Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R56HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2018 to 2018
$657k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL142765NHLBI NIH HHS R56 HL142765NIA NIH HHS R01 AG074185
6 · The paper itself

Abstract

backgroundProcedure volumes are associated with outcomes for many cardiovascular procedures, leading to guidelines on minimum volume thresholds for certain procedures; however, the volume-outcome relationship with left atrial appendage occlusion is poorly understood. As such, we sought to determine the relationship between hospital and physician volume and WATCHMAN left atrial appendage occlusion procedural success overall and with the new generation WATCHMAN FLX device.

methodsWe performed an analysis of WATCHMAN procedures (January 2019 to October 2021) from the National Cardiovascular Data Registry LAAO Registry. Three-level hierarchical generalized linear models were used to assess the adjusted relationship between procedure volume and procedural success (device released with peridevice leak <5 mm, no in-hospital major adverse events).

resultsAmong 87 480 patients (76.2±8.0 years; 58.8% men; mean CHA

conclusionsIn this contemporary national analysis, greater hospital and physician WATCHMAN volumes were associated with increased procedure success. The WATCHMAN FLX transition was associated with increased procedural success and less heterogeneity in outcomes across volume quartiles. These findings indicate the importance of understanding the volume-outcome relationship for individual left atrial appendage occlusion devices.

Indexed as

Atrial AppendageAtrial FibrillationCardiac CatheterizationHospitals, High-VolumeHospitals, Low-VolumeRegistriesAgedAged, 80 and overAtrial Function, LeftFemaleHumansMaleRisk AssessmentRisk FactorsStrokeTime Factorshospitalsleft atrial appendage closurelinear modelsphysiciansregistries

Identifiers

PMID38889251
PMCPMC11189610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.