Evidence map›Paper›PMID 38889222›Full record

ArticleJournal of speech, language, and hearing research : JSLHR2024

Social Communication Delay in an Unbiased Sample of Preschoolers With the

Jessica Klusek, Elizabeth Will, Thomas Christensen, Kelly Caravella, Abigail Hogan, Jennifer Sun, Jenna Smith, Amanda J Fairchild, Jane E Roberts

Abstract read
In one paragraph

Article in Journal of speech, language, and hearing research : JSLHR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Depression Symptom Trajectories in Mothers With the FMR1 Premutation Vary by CGG Repeat Length: A Longitudinal Study of 73 Women Spanning 20-75 Years of Age.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025
    Article
  3. Prelinguistic Communication Complexity of Children With Neurogenetic Syndromes.Journal of speech, language, and hearing research : JSLHR · 2025
    Article
  4. Reduced Respiratory Sinus Arrhythmia in Infants with theInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica KlusekDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia.ORCID 0000-0002-2818-0344
Elizabeth WillDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia.
Thomas ChristensenDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia.
Kelly CaravellaDepartment of Psychiatry, Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill School of Medicine.
Abigail HoganDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia.
Jennifer SunDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia.
Jenna SmithDepartment of Psychology, University of South Carolina, Columbia.
Amanda J FairchildDepartment of Psychology, University of South Carolina, Columbia.
Jane E RobertsDepartment of Psychology, University of South Carolina, Columbia.

Funding

Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Emergence, Stability and Predictors of Anxiety in Fragile X SyndromeR01MH107573 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Abigail Lee Hogan · 2016 to 2026
$6.1M
Supplement to The Emergence and Stability of Autism in Fragile X SyndromeR01MH090194 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ROBERTS, JANE E · 2011 to 2020
$5.4M
Aging Symptom Trajectories in Mother Carriers of the FMR1 PremutationR01AG073374 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Jessica Klusek · 2022 to 2026
$3.4M
Autonomic and Sensory Dysfunctions in FMR1 Conditions: Development, Mechanisms and ConsequencesR01HD106652 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Jane E Roberts · 2022 to 2026
$3.4M
Defining the Language Phenotype of the FMR1 PremutationR21DC017804 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KLUSEK, JESSICA · 2019 to 2021
$684k
Early Developmental Determinants and Pathways in Down syndromeK99HD105980 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILL, ELIZABETH · 2021 to 2022
$291k
NIA NIH HHS R01 AG073374NICHD NIH HHS K99 HD105980NICHD NIH HHS P50 HD103573NICHD NIH HHS R01 HD106652NIDCD NIH HHS R21 DC017804NIMH NIH HHS R01 MH090194NIMH NIH HHS R01 MH107573
6 · The paper itself

Abstract

purposeThe

methodEighteen children with the FXpm who were identified through cascade testing (89%) or screening at birth (11%) were compared to 21 matched typically developing children, aged 2-4 years. Participants completed standardized assessments of language (Mullen Scales of Early Learning) and adaptive communication (Vineland Adaptive Behavior Scales-II). Social communication was rated from seminaturalistic interaction samples using the Brief Observation of Social Communication Change.

resultsChildren with the FXpm showed delayed social communication development, with the magnitude of group differences highlighting social communication as a feature that distinguishes children with the FXpm from their peers (

conclusionsEarly screening and treatment of social communication delays may be key to optimizing outcomes for children with the FXpm. Further research is needed to replicate findings in a larger sample, delineate the trajectory and consequences of social communication difficulties across the life span in the FXpm, and determine the potential epidemiological significance of

Indexed as

Fragile X Messenger Ribonucleoprotein 1Child, PreschoolFemaleFragile X SyndromeHumansLanguage Development DisordersMaleMutationSocial Communication DisorderFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1

Identifiers

PMID38889222
PMCPMC11253810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.