Evidence map›Paper›PMID 38889214›Full record

ArticleCirculation. Cardiovascular imaging2024

Machine Learning Detects Symptomatic Plaques in Patients With Carotid Atherosclerosis on CT Angiography.

Francesco Pisu, Brady J Williamson, Valentina Nardi, Kosmas I Paraskevas, Josep Puig, Achala Vagal, Gianluca de Rubeis, Michele Porcu, Riccardo Cau, John C Benson and 5 more

Abstract readValidation Study
In one paragraph

Article in Circulation. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The initial application of RawVisionQuantitative imaging in medicine and surgery · 2026
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  14. Explainable Machine-Learning Model to Classify Culprit Calcified Carotid Plaque in Embolic Stroke of Undetermined Source.Journal of neuroimaging : official journal of the American Society of Neuroimaging
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Francesco PisuDepartment of Radiology, Azienda Ospedaliero-Universitaria, Monserrato (Cagliari), Italy (F.P., M.P., R.C., A.B., L.S.).ORCID 0000-0001-6044-6379
Brady J WilliamsonDepartment of Radiology, University of Cincinnati, Cincinnati, OH (B.J.W., A.V., A.M.).ORCID 0000-0002-1161-402X
Valentina NardiDepartment of Radiology, Mayo Clinic, Rochester, MN (V.N., J.C.B., G.L.).ORCID 0000-0003-4601-0434
Kosmas I ParaskevasDepartment of Vascular Surgery, Central Clinic of Athens, Athens, Greece (K.I.P.).ORCID 0000-0001-6865-2919
Josep PuigDepartment of Radiology (IDI), Hospital Universitari de Girona, Girona, Spain (J.P.).
Achala VagalDepartment of Radiology, University of Cincinnati, Cincinnati, OH (B.J.W., A.V., A.M.).ORCID 0000-0001-6428-6499
Gianluca de RubeisUOC Neuroradiology Diagnostic and Interventional, San Camillo-Forlanini Hospital, Rome, Italy (G.R.).ORCID 0000-0002-9567-6710
Michele PorcuDepartment of Radiology, Azienda Ospedaliero-Universitaria, Monserrato (Cagliari), Italy (F.P., M.P., R.C., A.B., L.S.).ORCID 0000-0002-3090-8541
Riccardo CauDepartment of Radiology, Azienda Ospedaliero-Universitaria, Monserrato (Cagliari), Italy (F.P., M.P., R.C., A.B., L.S.).ORCID 0000-0002-7910-1087
John C BensonDepartment of Radiology, Mayo Clinic, Rochester, MN (V.N., J.C.B., G.L.).ORCID 0000-0002-4038-5422
Antonella BalestrieriDepartment of Radiology, Azienda Ospedaliero-Universitaria, Monserrato (Cagliari), Italy (F.P., M.P., R.C., A.B., L.S.).ORCID 0000-0003-1864-3381
Giuseppe LanzinoDepartment of Radiology, Mayo Clinic, Rochester, MN (V.N., J.C.B., G.L.).ORCID 0000-0003-1479-465X
Jasjit S SuriStroke Diagnosis and Monitoring Division, Atheropoint LLC, Roseville, CA (J.S.S.).
Abdelkader MahammediDepartment of Radiology, University of Cincinnati, Cincinnati, OH (B.J.W., A.V., A.M.).
Luca SabaDepartment of Radiology, Azienda Ospedaliero-Universitaria, Monserrato (Cagliari), Italy (F.P., M.P., R.C., A.B., L.S.).ORCID 0000-0003-2870-3771

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to develop and validate a computed tomography angiography based machine learning model that uses plaque composition data and degree of carotid stenosis to detect symptomatic carotid plaques in patients with carotid atherosclerosis.

methodsThe machine learning based model was trained using degree of stenosis and the volumes of 13 computed tomography angiography derived intracarotid plaque subcomponents (eg, lipid, intraplaque hemorrhage, calcium) to identify plaques associated with cerebrovascular events. The model was internally validated through repeated 10-fold cross-validation and tested on a dedicated testing cohort according to discrimination and calibration.

resultsThis retrospective, single-center study evaluated computed tomography angiography scans of 268 patients with both symptomatic and asymptomatic carotid atherosclerosis (163 for the derivation set and 106 for the testing set) performed between March 2013 and October 2019. The area-under-receiver-operating characteristics curve by machine learning on the testing cohort (0.89) was significantly higher than the areas under the curve of traditional logit analysis based on the degree of stenosis (0.51,

conclusionsThis study presented an interpretable machine learning model that accurately identifies symptomatic carotid plaques using computed tomography angiography derived plaque composition features, aiding clinical decision-making.

Indexed as

Carotid Artery DiseasesComputed Tomography AngiographyMachine LearningPlaque, AtheroscleroticAgedCarotid ArteriesCarotid StenosisFemaleHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesSeverity of Illness Indexangiographyatherosclerosiscalibrationcarotid stenosishemorrhage

Identifiers

PMID38889214
PMCPMC11186714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.