ArticlePLoS biology2024
A closed-loop auditory stimulation approach selectively modulates alpha oscillations and sleep onset dynamics in humans.
Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Manipulating speech perception with amplitude-modulated kilohertz magnetic perturbation (AM-kTMP).bioRxiv : the preprint server for biology · 2026Article
- Learning the bistable cortical dynamics of the sleep-onset period.PLoS computational biology · 2026Article
- Nightingale: A multimodal approach combining EEG signals and audio features to enhance music therapy.PloS one · 2026Article
- Physical factor therapies for insomnia: a narrative review of mechanisms, clinical evidence, and phenotype-guided applications.Frontiers in psychiatry · 2026Review
- The Future of Non-Invasive Brain Stimulation in Sleep Medicine.Journal of sleep research · 2025Review
- Mechanism of Alzheimer's disease treatment by sound and light stimulation.Acta pharmaceutica Sinica. B · 2025Article
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Authors and funding
9 authors.
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Abstract
Alpha oscillations play a vital role in managing the brain's resources, inhibiting neural activity as a function of their phase and amplitude, and are changed in many brain disorders. Developing minimally invasive tools to modulate alpha activity and identifying the parameters that determine its response to exogenous modulators is essential for the implementation of focussed interventions. We introduce Alpha Closed-Loop Auditory Stimulation (αCLAS) as an EEG-based method to modulate and investigate these brain rhythms in humans with specificity and selectivity, using targeted auditory stimulation. Across a series of independent experiments, we demonstrate that αCLAS alters alpha power, frequency, and connectivity in a phase, amplitude, and topography-dependent manner. Using single-pulse-αCLAS, we show that the effects of auditory stimuli on alpha oscillations can be explained within the theoretical framework of oscillator theory and a phase-reset mechanism. Finally, we demonstrate the functional relevance of our approach by showing that αCLAS can interfere with sleep onset dynamics in a phase-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.