Evidence map›Paper›PMID 38889186›Full record

ArticleACS chemical biology2024

Replacement of Tyrosines by Unnatural Amino Acid Aminophenylalanine Leads to Metal-Mediated Aniline Free Radical Formation in a Copper Amine Oxidase.

Eric M Koehn, Albert Lang, Allison Flores, Claudia Lambert, Judith Klinman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric M KoehnDepartment of Chemistry and California Institute for Quantitative Biosciences, University of California-Berkeley, Berkeley, California 94720-3220, United States.ORCID 0000-0001-8195-9595
Albert LangDepartment of Molecular and Cell Biology, University of California-Berkeley, Berkeley, California 94720-3220, United States.
Allison FloresDepartment of Chemistry and California Institute for Quantitative Biosciences, University of California-Berkeley, Berkeley, California 94720-3220, United States.
Claudia LambertDepartment of Chemistry and California Institute for Quantitative Biosciences, University of California-Berkeley, Berkeley, California 94720-3220, United States.
Judith KlinmanDepartment of Chemistry and California Institute for Quantitative Biosciences, University of California-Berkeley, Berkeley, California 94720-3220, United States.ORCID 0000-0001-5734-2843

Funding

Looking in New Directions for Origins and Cryptic Mechanisms of Enzyme CatalysisR35GM118117 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KLINMAN, JUDITH P · 2016 to 2025
$7.5M
NIGMS NIH HHS R35 GM118117
6 · The paper itself

Abstract

Copper amine oxidases (CAOs) catalyze the oxidative deamination of primary amines to aldehyde, ammonia, and hydrogen peroxide as products and are widely distributed in bacteria, plants, and eukaryotes. These enzymes initiate the single turnover, post-translational conversion of an active site tyrosine to the redox cofactor 2,4,5-trihydroxyphenylalanine quinone (TPQ), subsequently employing TPQ to catalyze steady-state amine oxidation. The mechanisms of TPQ biogenesis and steady-state amine oxidation have been studied extensively, with consensus mechanisms proposed for both reactions. One unresolved issue has been whether the Cu

Indexed as

Amine Oxidase (Copper-Containing)Aniline CompoundsCopperTyrosineCatalytic DomainFree RadicalsOxidation-ReductionPhenylalanineAmine Oxidase (Copper-Containing)anilineAniline CompoundsCopperFree RadicalsPhenylalanineTyrosine

Identifiers

PMID38889186
PMCPMC11407504

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.