Evidence map›Paper›PMID 38889160›Full record

Trial reportPloS one2024

Functioning and quality of life among treatment-engaged adults with psychotic disorders in urban Tanzania: Baseline results from the KUPAA clinical trial.

Joseph R Egger, Sylvia Kaaya, Praxeda Swai, Paul Lawala, Liness Ndelwa, Joseph Temu, Eliasa Swata Bukuku, Ellen Lukens, Ezra Susser, Lisa Dixon and 5 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04013932 (Family Psychoeducation for Adults With Psychotic Disorders in Tanzania), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04013932 nacompletednot on this map

Family Psychoeducation for Adults With Psychotic Disorders in Tanzania (Pilot Clinical Trial of KUPAA)

TypeinterventionalSponsorDuke UniversityRan2019 to 2020Enrolled66ConditionsSchizophrenia Spectrum and Other Psychotic Disorders, Mental Disorders, SevereArmsKUPAA Intervention Group (Culturally Tailored Family Psychoeducation)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joseph R EggerDuke Global Health Institute, Duke University, Durham, NC, United States of America.ORCID 0000-0002-0862-9511
Sylvia KaayaMuhimbili University of Health & Allied Sciences, Dar es Salaam, Tanzania.
Praxeda SwaiMuhimbili University of Health & Allied Sciences, Dar es Salaam, Tanzania.
Paul LawalaMbeya Zonal Referral Hospital, Mbeya, Tanzania.
Liness NdelwaMbeya Zonal Referral Hospital, Mbeya, Tanzania.
Joseph TemuMuhimbili University of Health & Allied Sciences, Dar es Salaam, Tanzania.
Eliasa Swata BukukuMbeya Zonal Referral Hospital, Mbeya, Tanzania.
Ellen LukensSchool of Social Work, Columbia University, New York, NY, United States of America.
Ezra SusserNew York State Psychiatric Institute, New York, NY, United States of America.
Lisa DixonNew York State Psychiatric Institute, New York, NY, United States of America.
Anna MinjaMuhimbili University of Health & Allied Sciences, Dar es Salaam, Tanzania.
Rosarito ClariDuke Global Health Institute, Duke University, Durham, NC, United States of America.
Alyssa MartinezDuke Global Health Institute, Duke University, Durham, NC, United States of America.
Jennifer HeadleyDuke Global Health Institute, Duke University, Durham, NC, United States of America.
Joy Noel BaumgartnerDuke Global Health Institute, Duke University, Durham, NC, United States of America.ORCID 0000-0002-1783-8972

Funding

Family psychoeducation for adults with psychotic disorders in TanzaniaR34MH106663 · NIMH · DUKE UNIVERSITY · PI BAUMGARTNER, JOY NOEL · 2017 to 2019
$644k
NIMH NIH HHS R34 MH106663
6 · The paper itself

Abstract

backgroundThere is a treatment gap for those living with severe mental illnesses in low- and middle-income countries, yet not enough is known about those who are currently accessing clinical services. A better understanding of potentially modifiable factors associated with functioning and quality of life will help inform policies and programming.

aimsTo describe the functioning and quality of life for a psychiatric treatment-engaged population living with psychotic disorders in two urban areas of Tanzania, and to explore their respective correlates.

methodsThis study analyzed cross-sectional data from 66 individuals enrolled in the Kuwezeshana Kupata Uzima (KUPAA) pilot clinical trial who had a diagnosis of schizophrenia or schizoaffective disorder, recent relapse, and who were receiving outpatient treatment. Baseline functioning (WHO Disability Assessment Schedule 2.0) and quality of life (WHO Quality of Life BREF scale) were measured. Univariable and multivariable regression analyses were conducted to determine correlates of functioning and quality of life.

resultsAdjusted analyses indicated that higher disability was associated with higher food insecurity, more symptomatology, more self-stigma, less instrumental support, less hope, lower self-efficacy, and/or lower levels of family functioning. Higher quality of life was associated with higher levels of self-efficacy, more hopefulness, more instrumental support, less self-stigma, and better family functioning.

conclusionsIdentification of factors associated with disability and quality of life can help clinicians and policymakers, as well as consumers of mental health services, to better co-design and target psychosocial interventions to optimize their impact in low-resource settings.

trial registrationTrial registration: ClinicalTrials.gov # NCT04013932, July 10, 2019.

Indexed as

Psychotic DisordersQuality of LifeAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedSchizophreniaTanzaniaUrban PopulationYoung Adult

Identifiers

PMID38889160
PMCPMC11185462

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.