Evidence map›Paper›PMID 38889150›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness.

Sarah K Schultz, Christopher D Katanski, Mateusz Halucha, Noah Peña, Richard P Fahlman, Tao Pan, Ute Kothe

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. Article
  4. The impact of psuedouridine modification on human tRNA.Biochemical Society transactions · 2026
    Review
  5. Article
  6. RNase 4 improves bottom-up modification mapping ofbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. TRMT6/TRMT61A-mediated tRNA mCellular & molecular biology letters · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Functions and therapeutic applications of pseudouridylation.Nature reviews. Molecular cell biology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah K SchultzDepartment of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Christopher D KatanskiDepartment of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-1707-081X
Mateusz HaluchaDepartment of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637.
Noah PeñaDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-9079-4638
Richard P FahlmanDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Tao PanDepartment of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637.
Ute KotheDepartment of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0002-2744-7334

Funding

University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPAS-2020-00010Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2020-04965NIGMS NIH HHS R25 GM109439
6 · The paper itself

Abstract

Almost all elongator tRNAs (Transfer RNAs) harbor 5-methyluridine 54 and pseudouridine 55 in the T arm, generated by the enzymes TrmA and TruB, respectively, in

Indexed as

Escherichia coliRNA, TransferEscherichia coli ProteinsProtein BiosynthesisRNA Processing, Post-TranscriptionaltRNA MethyltransferasesEscherichia coli ProteinsRNA, TransfertRNA Methyltransferasesaminoacylationmethylationprotein synthesispseudouridinetRNA modification

Identifiers

PMID38889150
PMCPMC11214086

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.