ArticleClinical oral investigations2024
Exploring the causal effects of sleep characteristics on TMD-related pain: a two-sample Mendelian randomization study.
Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management.Neuroscience bulletin · 2026Review
- The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.BMC oral health · 2026Article
- Association of simple snoring and myogenous temporomandibular disorders based on polysomnographic examination.Journal of oral & facial pain and headache · 2026Observational
- TikTok as a Source of Information on Temporomandibular Disorders: Reliable Health Education or Misinformation?Journal of clinical and experimental dentistry · 2025Review
- Orofacial pain/headache interlaced to insomnia, sleep apnea and periodic limb movement during sleep/restless leg syndrome: a critical and comprehensive review with insights into social determinants.Journal of oral & facial pain and headache · 2025Review
- Genetic prediction of blood metabolites and causal relationships with pain associated with temporomandibular disorders: a Mendelian randomization study.Journal of oral & facial pain and headache · 2025Article
- Arthrocentesis of Temporomandibular Joints-A Clinical Comparative Study.Life (Basel, Switzerland) · 2024Article
- The potential association between sedentary behaviors and risk of temporomandibular disorders: evidence from Mendelian randomization analysis.Journal of oral & facial pain and headache · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study was to explore the causal effects of sleep characteristics on temporomandibular disorder (TMD)-related pain using Mendelian randomization (MR) analysis. MATERIALS AND
methodsFive sleep characteristics (short sleep, insomnia, chronotype, snoring, sleep apnea) were designated as exposure factors. Data were obtained from previous publicized genome-wide association studies and single nucleotide polymorphisms (SNPs) strongly associated with them were utilized as instrumental variables (IVs). TMD-related pain was designed as outcome variable and sourced from the FinnGens database. MR analysis was employed to explore the causal effects of the five sleep characteristics on TMD-related pain. The causal effect was analyzed using the inverse variance-weighted (IVW), weighted median, and MR-Egger methods. Subsequently, sensitivity analyses were conducted using Cochran's Q tests, funnel plots, leave-one-out analyses, and MR-Egger intercept tests.
resultsA causal effect of short sleep on TMD-related pain was revealed by IVW (OR: 1.60, 95% CI: 1.06-2.41, P = 0.026). No causal relationship was identified between other sleep characteristics (insomnia, chronotype, snoring, sleep apnea) and TMD-related pain.
conclusionsOur study suggests that short sleep may increase the risk of TMD-related pain, while there was no causal relationship between other sleep characteristics and TMD-related pain. Further studies are warranted to deepen and definitively clarify their relationship. CLINICAL RELEVANCE: These findings reveal that the short sleep may be a risk factor of TMD-related pain and highlight the potential therapeutical effect of extending sleep time on alleviating TMD-related pain.
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