Evidence map›Paper›PMID 38888672›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2024

Factors associated with self-rated health in people with late-stage parkinson's and cognitive impairment.

Jennifer S Pigott, Megan Armstrong, Nathan Davies, Daniel Davis, Bastiaan R Bloem, Stefan Lorenzl, Wassilios G Meissner, Per Odin, Joaquim J Ferreira, Richard Dodel and 1 more

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer S PigottClinical Neurosciences, Queen Square Institute of Neurology, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.ORCID http://orcid.org/0000-0002-0951-7941
Megan ArmstrongCentre for Ageing Population Studies, Research Department of Primary Care and Population Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-6773-9393
Nathan DaviesCentre for Ageing Population Studies, Research Department of Primary Care and Population Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-7757-5353
Daniel DavisMRC Unit for Lifelong Health and Ageing, University College London, London, UK.ORCID http://orcid.org/0000-0002-1560-1955
Bastiaan R BloemDonders Institute for Brain, Cognition and Behavior, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-6371-3337
Stefan LorenzlInstitute for Palliative Care, Paracelsus Medical University, Salzburg, Austria.ORCID http://orcid.org/0000-0002-1165-0821
Wassilios G MeissnerService de Neurologie des Maladies Neurodégénératives, IMNc, IMN, UMR 5293, CHU de Bordeaux, Univ. de Bordeaux, CNRS, 33000, Bordeaux, France.ORCID http://orcid.org/0000-0003-2172-7527
Per OdinDivision of Neurology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.ORCID http://orcid.org/0000-0002-0756-7478
Joaquim J FerreiraDept. Medicine, University of Otago, Christchurch, and New Zealand Brain Research Institute, Christchurch, New Zealand.ORCID http://orcid.org/0000-0003-3950-5113
Richard DodelDepartment of Geriatric Medicine, University Duisburg Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-2044-6299
Anette SchragClinical Neurosciences, Queen Square Institute of Neurology, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK. a.schrag@ucl.ac.uk.ORCID http://orcid.org/0000-0002-9872-6680

Funding

European Commission ES/L009250/1Rosetrees Trust RCP-2020\11Royal College of Physicians RCP-2020\11
6 · The paper itself

Abstract

purposeTo investigate the contributors to self-rated health in people with late-stage Parkinson's disease (PD) and cognitive impairment.

methodsA secondary analysis of baseline data from the international Care of Late-Stage Parkinsonism (CLaSP) cohort study was conducted. Participants with PD and either dementia or mild cognitive impairment or MMSE < 24/30 in the absence of major depression were included if they had completed the EQ-5D-3L assessment (n = 277). Factors associated with self-rated health (EQ-5D-3L Index and Visual Analogue Scale) were investigated through multivariable linear regression.

resultsMore severe PD (motor and non-motor) was associated with worse self-rated health. The EQ-5D-3L dimensions of Mobility, Self-Care and Usual Activities were almost universally affected; the latter two particularly severely. Being unable to perform usual activities or having moderate to extreme anxiety or depression were significantly associated with EQ-5D-3L Visual Analogue Scale, suggesting these are particularly valued. Worse motor impairment and function and the non-motor symptom domains of mood, perception, sexual function, and miscellaneous (e.g., pain) were associated with worse self-rated health, whereas greater burden of gastrointestinal symptoms was associated with better self-rated health in multivariate analysis. Better self-rated health was associated with recent PD nurse consultation, and higher doses of dopaminergic medication.

conclusionImprovement of activities of daily living, mood and anxiety should be prioritised in clinical practice, with consideration of perception and sexual function in this population. Recent nurse consultations and higher antiparkinsonian doses are associated with better self-rated health, suggesting there is no room for a therapeutic nihilism in this population of people within a complex phase of PD.

Indexed as

Cognitive DysfunctionParkinson DiseaseActivities of Daily LivingAgedAged, 80 and overCohort StudiesFemaleHealth StatusHumansMaleMiddle AgedQuality of LifeSelf ReportSeverity of Illness IndexSurveys and QuestionnairesCognitive impairmentParkinson’s diseaseParkinson’s disease dementiaSelf-rated health.

Identifiers

PMID38888672
PMCPMC11390760

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.