SynthesisAging clinical and experimental research2024
Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies.
Synthesis in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Osteosarcopenia: More Than the Sum of Its Parts? A Community-Based Study Across Sarcopenia Definitions.Calcified tissue international · 2026Article
- From Molecular Pathways to Artificial Intelligence: Advancing the Understanding and Management of Osteosarcopenia.International journal of molecular sciences · 2026Review
- Immunometabolic Remodeling in Osteosarcopenia: Inflammaging, Mitochondrial Dysfunction, Gut-Derived Metabolites and Therapeutic Opportunities.Metabolites · 2026Review
- Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- A Randomized Study Evaluating the Effect of Ossein-Hydroxyapatite Complex on the Functional Outcomes of Patients After Conservative Treatment of Distal Radius Fracture.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives.Health science reports · 2026Article
- Food insecurity as a predictor of all-cause mortality and premature mortality among older adults: a longitudinal cohort analysis of ELSA study.Aging clinical and experimental research · 2026Article
- Review
- Impact of osteosarcopenia in older people on prognosis following major surgery: a scoping review.PeerJ · 2026Article
- The association between body fat distribution and osteosarcopenia in older adults: evidence from the PoCOsteo study.Aging clinical and experimental research · 2025Article
- Osteosarcopenia as a risk factor for fractures and mortality - 19-year follow-up of a population-based sample.Aging clinical and experimental research · 2025Article
- Osteoporosis and sarcopenia: two sides of the same coin.European geriatric medicine · 2025Article
- Sarcopenia - the need for an Asian perspective.Aging clinical and experimental research · 2025Review
- Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture.Aging clinical and experimental research · 2025Article
- Conference Abstracts "Bridges in Rehabilitation" of the 2Journal of frailty, sarcopenia and falls · 2025Article
- Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications.World journal of cardiology · 2025Review
- Calf circumference predicts changes of bone mineral density in postmenopausal osteoporotic women receiving denosumab.Aging clinical and experimental research · 2025Article
- Osteosarcopenia and geriatric hip fractures: Current concepts.World journal of orthopedics · 2025Review
- Ten-year atherosclerotic cardiovascular disease risk score in post-menopausal women with low bone mineral density.Aging clinical and experimental research · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsOsteosarcopenia is a recently recognized geriatric syndrome. The association between osteosarcopenia and mortality risk is still largely underexplored. In this systematic review with meta-analysis of prospective cohort studies, we aimed to explore whether osteosarcopenia could be associated with a higher mortality risk.
methodsSeveral databases were searched from the inception to 16th February 2024 for prospective cohort studies dealing with osteosarcopenia and mortality. We calculated the mortality risk in osteosarcopenia vs. controls using the most adjusted estimate available and summarized the data as risk ratios (RRs) with their 95% confidence intervals (CIs). A random-effect model was considered for all analyses.
resultsAmong 231 studies initially considered, nine articles were included after exclusions for a total of 14,429 participants (mean age: 70 years; 64.5% females). The weighted prevalence of osteosarcopenia was 12.72%. Over a mean follow-up of 6.6 years and after adjusting for a mean of four covariates, osteosarcopenia was associated with approximately 53% increased risk of mortality (RR: 1.53; 95% CI: 1.28-1.78). After accounting for publication bias, the re-calculated RR was 1.48 (95%CI: 1.23-1.72). The quality of the studies was generally good, as determined by the Newcastle Ottawa Scale.
conclusionsOsteosarcopenia was significantly linked with an increased risk of mortality in older people, indicating the need to consider the presence of osteoporosis in patients with sarcopenia, and vice versa, since the combination of these two conditions typical of older people may lead to further complications, such as mortality.
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