Evidence map›Paper›PMID 38888655›Full record

ArticlePlant molecular biology2024

Five amino acid mismatches in the zinc-finger domains of Cellulose Synthase 5 and Cellulose Synthase 6 cooperatively modulate their functional properties by controlling homodimerization in Arabidopsis.

Sungjin Park, Shi-You Ding

Abstract read
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In one paragraph

Article in Plant molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genome-Wide Identification and Functional Characterization ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sungjin ParkDepartment of Plant Biology, Michigan State University, 612 Wilson Road, East Lansing, MI, 48824, USA.
Shi-You DingDepartment of Plant Biology, Michigan State University, 612 Wilson Road, East Lansing, MI, 48824, USA. sding@msu.edu.ORCID http://orcid.org/0000-0002-7676-677X

Funding

U.S. Department of Energy DE-SC0019072
6 · The paper itself

Abstract

Cellulose synthase 5 (CESA5) and CESA6 are known to share substantial functional overlap. In the zinc-finger domain (ZN) of CESA5, there are five amino acid (AA) mismatches when compared to CESA6. These mismatches in CESA5 were replaced with their CESA6 counterparts one by one until all were replaced, generating nine engineered CESA5s. Each N-terminal enhanced yellow fluorescent protein-tagged engineered CESA5 was introduced to prc1-1, a cesa6 null mutant, and resulting mutants were subjected to phenotypic analyses. We found that five single AA-replaced CESA5 proteins partially rescue the prc1-1 mutant phenotypes to different extents. Multi-AA replaced CESA5s further rescued the mutant phenotypes in an additive manner, culminating in full recovery by CESA5

Indexed as

ArabidopsisArabidopsis ProteinsGlucosyltransferasesAmino Acid SequenceCelluloseMutationPhenotypeProtein MultimerizationZinc FingersArabidopsis ProteinsCellulosecellulose synthaseGlucosyltransferasesPRC1 protein, ArabidopsisAmino acid mismatchesCellulose synthase (CESA)Cellulose synthase complex (CSC)CSC assemblyHomodimerizationZinc-finger domain

Identifiers

PMID38888655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.